Skip to main content

Pediococcus pentosaceus PP04 Ameliorates High-Fat Diet-Induced Hyperlipidemia by Regulating Lipid Metabolism in C57BL/6N Mice.

  • 2020-12-10
  • Journal of Agricultural and Food Chemistry 68(51)
    • Yu Wang
    • Ying You
    • Yuan Tian
    • Haiyue Sun
    • Xia Li
    • Xiujuan Wang
    • Yuhua Wang
    • Jingsheng Liu

Abstract

In this study, Pediococcus pentococcus PP04 isolated from the Northeast pickled cabbage had good gastrointestinal tolerance and can colonize in the intestine stably. C57BL/6N mice were fed a high-fat diet to build animal models and treated with Pediococcus pentosaceus PP04 to evaluate the antihyperlipidemia effect. After 8 weeks, the indicators of hyperlipidemia, liver injury, and inflammation were measured. The treatment of P. pentosaceus PP04 reduced the gain of total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), free fatty acids (FFAs), leptin, alanine aminotransferase (ALT), aspartate aminotransferase (AST), lipopolysaccharides (LPS), and tumor necrosis factor-α (TNF-α) significantly. The western blotting results suggested P. pentosaceus PP04 ameliorated high-fat diet-induced hyperlipidemia by the AMPK signaling pathway, which stimulated lipolysis via upregulation of PPARα and inhibited lipogenesis by downregulation of SREBP-1c, fatty acid synthase (FAS), and stearoyl-CoA desaturase-1 (SCD1) mainly. Furthermore, P. pentosaceus PP04 improved high-fat diet-induced oxidative stress effectively by triggering the Nrf2/CYP2E1 signaling pathway that enhanced the antioxidant activity including superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px).

Keywords: AMPK signaling pathway; Pediococcus pentosaceus PP04; hyperlipidemia; oxidative stress.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Pediococcus pentosaceus KABP™-041Improved Blood Lipid MetabolismBeneficial
Large
Pediococcus pentosaceus KABP™-041Reduced Hepatic Oxidative StressBeneficial
Large
Pediococcus pentosaceus KABP™-041Reduced Inflammation LevelsBeneficial
Moderate
Pediococcus pentosaceus KABP™-041Reduced Liver Injury IndicatorsBeneficial
Large
Pediococcus pentosaceus KABP™-041Reduced Total Cholesterol LevelsBeneficial
Moderate
Pediococcus pentosaceus MAK99P15PEnhanced Antioxidant ActivityBeneficial
Large
Pediococcus pentosaceus MAK99P15PReduced Free Fatty Acid LevelsBeneficial
Moderate
Pediococcus pentosaceus MAK99P15PReduced Inflammation LevelsBeneficial
Moderate
Pediococcus pentosaceus MAK99P15PReduced Liver InjuryBeneficial
Large
Pediococcus pentosaceus MAK99P15PReduced Low-Density Lipoprotein LevelBeneficial
Moderate
Pediococcus pentosaceus MAK99P15PReduced Total Cholesterol LevelsBeneficial
Moderate
Pediococcus pentosaceus MAK99P15PReduced Triglyceride LevelsBeneficial
Moderate
Pediococcus pentosaceus PP06Enhanced Antioxidant ActivityBeneficial
Large
Pediococcus pentosaceus PP06Reduced Free Fatty Acid LevelsBeneficial
Moderate
Pediococcus pentosaceus PP06Reduced Inflammation LevelsBeneficial
Moderate
Pediococcus pentosaceus PP06Reduced Liver InjuryBeneficial
Large
Pediococcus pentosaceus PP06Reduced Low-Density Lipoprotein LevelBeneficial
Moderate
Pediococcus pentosaceus PP06Reduced Total Cholesterol LevelsBeneficial
Moderate
Pediococcus pentosaceus PP06Reduced Triglyceride LevelsBeneficial
Moderate
⬆ Back to top
Pillser
Supplement Research and Comparison Website: evidence-based information about supplements, their benefits, potential risks, and their efficacy.
Receive updates about our products, services, sales, and special offers. Unsubscribe anytime. See our Privacy Policy for details on how we handle your information.

Join Our Community

Use support@pillser.com to get in touch.