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Peptidoglycan from Bifidobacterium bifidum G9-1 induces IgA secretion in Peyer's patch-derived cells.

  • 2026-01-06
  • Bioscience of microbiota, food and health 45(1)
    • Hiroaki Konishi
    • Koji Yamamoto
    • Aki Sakatani
    • Tatsuya Dokoshi
    • Yutaka Makizaki
    • Yoshiki Tanaka
    • Hiroshi Ohno
    • Kentaro Moriichi
    • Mikihiro Fujiya

Study Design

Population
Peyer's patch (PP)-derived cells
Methods
We investigated the IgA-inducing capacity of heat-killed Bifidobacterium bifidum G9-1 (BBG9-1) using Peyer's patch (PP)-derived cells. Heat-killed BBG9-1, but not its culture supernatant, significantly enhanced IgA secretion and cell aggregation. Component analysis revealed that peptidoglycan (PG), but not lipoteichoic acid (LTA), isolated from BBG9-1 significantly stimulated IgA secretion.
Immunoglobulin A (IgA) plays a key role in mucosal immunity. We investigated the IgA-inducing capacity of heat-killed Bifidobacterium bifidum G9-1 (BBG9-1) using Peyer's patch (PP)-derived cells. Heat-killed BBG9-1, but not its culture supernatant, significantly enhanced IgA secretion and cell aggregation. Compared with other Gram-positive bacteria, BBG9-1 showed a stronger IgA-inducing effect. Component analysis revealed that peptidoglycan (PG), but not lipoteichoic acid (LTA), isolated from BBG9-1 significantly stimulated IgA secretion. These findings suggest that PG from BBG9-1 is a key factor in IgA induction, supporting its potential application in modulating mucosal immune responses.

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