Peptidoglycan from Bifidobacterium bifidum G9-1 induces IgA secretion in Peyer's patch-derived cells.

2026
Bioscience of microbiota, food and health 45(1)

PubMed: 41492380
DOI: 10.12938/bmfh.2025-040

Study Design

Population: Peyer's patch (PP)-derived cells
Methods: We investigated the IgA-inducing capacity of heat-killed Bifidobacterium bifidum G9-1 (BBG9-1) using Peyer's patch (PP)-derived cells. Heat-killed BBG9-1, but not its culture supernatant, significantly enhanced IgA secretion and cell aggregation. Component analysis revealed that peptidoglycan (PG), but not lipoteichoic acid (LTA), isolated from BBG9-1 significantly stimulated IgA secretion.

Immunoglobulin A (IgA) plays a key role in mucosal immunity. We investigated the IgA-inducing capacity of heat-killed Bifidobacterium bifidum G9-1 (BBG9-1) using Peyer's patch (PP)-derived cells. Heat-killed BBG9-1, but not its culture supernatant, significantly enhanced IgA secretion and cell aggregation. Compared with other Gram-positive bacteria, BBG9-1 showed a stronger IgA-inducing effect. Component analysis revealed that peptidoglycan (PG), but not lipoteichoic acid (LTA), isolated from BBG9-1 significantly stimulated IgA secretion. These findings suggest that PG from BBG9-1 is a key factor in IgA induction, supporting its potential application in modulating mucosal immune responses.

Research Insights

Supplement	Dose	Health Outcome	Effect Type	Effect Size	Source
Bifidobacterium bifidum G9-1	—	Increased Intestinal IgA Secretion	Beneficial	Moderate	View source Heat-killed BBG9-1, but not its culture supernatant, significantly enhanced IgA secretion and cell aggregation.