Phytochemicals, Two New Sulphur Glycosides and Two New Natural Products, from Shepherd's Purse Seed and Their Activities.
- 2024-08-31
- Molecules (Basel, Switzerland) 29(17)
- Zhen-Zhen Wei
- Chun-Bo Ge
- Yu-Jie Wang
- Bin Li
- Ying Tian
- Ti-Qiang Zhou
- Shu-Chen Liu
- Jian-Feng Yi
- PubMed: 39274993
- DOI: 10.3390/molecules29174145
Study Design
- Methods
- Extraction and isolation of compounds from shepherd's purse seed; structure determination by IR, NMR, and MS; docking to NF-κB; anti-radiation activity assay.
Two new sulfur glycosides, bursapastoris A-B (3-4), were extracted and isolated from shepherd's purse seed, along with two new natural products, 11-(methylsulfinyl)undecanoic acid (2) and 10-(methylsulfinyl)decanoic acid (1). Their structures were determined though infrared spectroscopy, one-dimensional nuclear magnetic resonance (1H and 13C), and electrospray ionization mass spectrometry. Additionally, the structures of 3-4 were further identified by two-dimensional nuclear magnetic resonance (HMBC, HSQC, 1H-1H COSY, and NOESY). Compounds 1-4 showed relatively favorable docking to NF-κB. Unfortunately, we only discovered that compound 1-4 had weak anti-radiation activity at present. Therefore, further research regarding the biological activity of these organosulfur compounds is required at a later stage.