Pleurotus eryngii improves postprandial glycaemia, hunger and fullness perception, and enhances ghrelin suppression in people with metabolically unhealthy obesity.

2021-11-16
Pharmacological research 175
- Stamatia-Angeliki Kleftaki
- Stamatia Simati
- Charalampia Amerikanou
- Aristea Gioxari
- Chara Tzavara
- Georgios I Zervakis
- Nick Kalogeropoulos
- Alexander Kokkinos
- Andriana C Kaliora

PubMed: 34798266
DOI: 10.1016/j.phrs.2021.105979

Study Design

Type: Randomized Controlled Trial (RCT)
Population: nineteen volunteers with metabolically unhealthy obesity
Methods: acute, randomized, crossover-designed trial comparing a meal with Pleurotus eryngii and a control meal
Blinding: Open-label
Duration: acute
Funding: Unclear

The aim of this study was to examine potential postprandial benefits of Pleurotus eryngii in nineteen volunteers with metabolically unhealthy obesity. An acute, randomized, crossover-designed trial comparing a meal with Pleurotus eryngii and a control meal was performed. The two meals matched in macronutrient and caloric content. Participants consumed both meals in random order after an overnight fast. Blood samples were drawn before and 30, 60, 90, 120, 150 and 180 min after meal consumption (in total 266 samples) to determine glucose, insulin, ghrelin, peptide YY, glucagon-like peptide-1 and glicentin. Visual analog scales measuring the subjective perception of hunger and fullness were completed at the same time points. The test meal resulted in lower glucose incremental area under the curve (iAUC). Additionally, the iAUC of the ghrelin response over time was substantially lower after the test meal (p = 0.033). Lower desire to eat and higher fullness was reflected by significantly lower hunger iAUC (p = 0.046) and higher fullness iAUC (p = 0.042) after the test meal. No differences in insulin, PYY, GLP-1 and glicentin were observed. Pleurotus eryngii can ameliorate postprandial glycaemia, appetite and regulate ghrelin levels at the postprandial state. This effect is attributed to the bioactive polysaccharides that inhibit the activity of enzymes catalysing carbohydrate hydrolysis, cause a delayed gastric emptying and glucose absorption.

Research Insights

king trumpet mushroom→Improved Insulin Levels
No differences in insulin, PYY, GLP-1 and glicentin were observed.
Effect
Neutral
Effect size
Small
king trumpet mushroom→Increased Fullness
Lower desire to eat and higher fullness was reflected by significantly lower hunger iAUC (p = 0.046) and higher fullness iAUC (p = 0.042)
Effect
Beneficial
Effect size
Small
king trumpet mushroom→Reduced Ghrelin Level
the iAUC of the ghrelin response over time was substantially lower after the test meal (p = 0.033)
Effect
Beneficial
Effect size
Small
king trumpet mushroom→Reduced Glicentin Level
No differences in insulin, PYY, GLP-1 and glicentin were observed.
Effect
Neutral
Effect size
Small
king trumpet mushroom→Reduced Glucagon-like Peptide-1 Level
No differences in insulin, PYY, GLP-1 and glicentin were observed.
Effect
Neutral
Effect size
Small
king trumpet mushroom→Reduced Hunger
Lower desire to eat and higher fullness was reflected by significantly lower hunger iAUC (p = 0.046) and higher fullness iAUC (p = 0.042)
Effect
Beneficial
Effect size
Small
king trumpet mushroom→Reduced Peptide YY Level
No differences in insulin, PYY, GLP-1 and glicentin were observed.
Effect
Neutral
Effect size
Small
king trumpet mushroom→Reduced Postprandial Glucose
The test meal resulted in lower glucose incremental area under the curve (iAUC).
Effect
Beneficial
Effect size
Small