Polyphosphate from Lactic Acid Bacteria: A Functional Molecule for Food and Health Applications.
- 2025-06-23
- Foods (Basel, Switzerland) 14(13)
- PubMed: 40646963
- DOI: 10.3390/foods14132211
Study Design
- Type
- Review
The linear polymer polyphosphate (polyP) is found across all three domains of life and fulfills diverse physiological functions, including phosphorus storage, chaperone activity, and stress tolerance. In bacteria, polyP synthesis is catalyzed by polyphosphate kinase (Ppk), whereas its degradation is carried out by exopolyphosphatases (Ppx). Intracellular polyP levels are determined by the balance between these opposing enzymatic activities, although the regulatory mechanisms governing this balance remain incompletely understood. In higher eukaryotes, polyP participates in diverse physiological processes from cell signaling to blood clotting. In relation to this, polyP from Levilactobacillus brevis has been identified as a protective factor against intestinal damage in a mouse model of acute colitis. Subsequent evidence has confirmed that polyP can confer beneficial effects on human intestinal health, prompting an increased interest in the production of polyP by probiotic lactic acid bacteria. Furthermore, polyP is extensively used in the food industry to enhance food quality, preservation, and nutritional value. This review summarizes the current knowledge on polyP metabolism in these bacteria and explores its functional properties and potential applications.
Research Insights
| Supplement | Dose | Health Outcome | Effect Type | Effect Size | Source |
|---|---|---|---|---|---|
| Lactobacillus brevis SBC8803 | — | Improved Intestinal Health | Beneficial | Moderate | View sourcepolyP from Levilactobacillus brevis has been identified as a protective factor against intestinal damage in a mouse model of acute colitis. Subsequent evidence has confirmed that polyP can confer beneficial effects on human intestinal health |