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Abstract

Natto is a well-known traditional Japanese food produced by fermenting soybeans with Bacillus subtilis var natto. Here we found that the water-soluble viscous fraction of natto inhibits sucrose- or glucose-induced hyperglycemia in silkworms. The water-soluble viscous fraction treated with DNase I, RNase A, and proteinase K, followed by phenol extraction also suppressed sucrose-induced hyperglycemia in silkworms. The enzyme-treated polysaccharide fraction of natto inhibits glucose uptake by Caco-2 cells, human intestinal epithelial cells. These findings suggest that the polysaccharide components of natto selected on the basis of their suppressive effects on sucrose-induced hyperglycemia in silkworms inhibit glucose uptake by human intestinal cells.

Keywords: Glucose uptake; natto; polysaccharide; silkworm; sucrose-induced hyperglycemia.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
NattoReduced Glucose UptakeBeneficial
Moderate
NattoReduced Hyperglycemic ResponseBeneficial
Moderate
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