Poor sleep quality among patients with Parkinson's disease: a meta-analysis and systematic review.

2025-07-16
Frontiers in psychiatry 16
- Tong Leong Si
- Yue-Ying Wang
- Jia-Xin Li
- Wei Bai
- He-Li Sun
- Shu-Ying Rao
- Han-Yu Zhu
- Gabor S Ungvari
- Zhaohui Su
- Teris Cheung
- Chee H Ng
- Yu-Tao Xiang
- Gang Wang

PubMed: 40740260
DOI: 10.3389/fpsyt.2025.1606743

Study Design

Type: Systematic Review
Population: patients with Parkinson's disease (PD)
Methods: Systematic review and meta-analysis following PRISMA and MOOSE guidelines, searching multiple databases from inception to November 4, 2023, with pooled prevalence calculation and meta-regression

Objective

Poor sleep quality is common among patients with Parkinson's disease (PD), although the reported prevalence rates vary between studies. This meta-analysis examined the overall prevalence of poor sleep quality in patients with PD and identified potential factors contributing to the differences in prevalence across studies.

Methods

Both PRISMA and MOOSE guidelines were applied in this meta-analysis. A systematic search was conducted in PubMed, EMBASE, PsycINFO, Web of Science, CNKI and Wangfang from their inception to November 4, 2023. Studies were selected based on predefined PICOS criteria (i.e., PD patients, prevalence of poor sleep quality, cross-sectional/cohort designs). Study quality/risk of bias was assessed using a standardized 8-item tool. Pooled prevalence was calculated sources of heterogeneity (e.g., age, sex, depression, anxiety, cognition scores, disease severity, and medication dose) were explored via subgroup and meta-regression analyses. A random-effects model was utilized to calculate the overall prevalence and corresponding 95% confidence intervals (CIs).

Results

In total, 63 studies involving 9,382 PD patients were included. The overall prevalence of poor sleep quality was 58.07% (95% CI: 54.26-61.88%). Higher rates were related to various factors including studies from Europe & Central Asia, Upper middle income countries, mixed patient sources, lower diagnostic cutoffs, and use of Movement Disorder Society PD criteria. Meta-regression analysis showed that late onset PD was associated with poorer sleep quality in patients with PD.

Conclusion

Poor sleep quality is common in PD patients. Regular monitoring of sleep quality and promotion of sleep hygiene should be prioritized in the management of patients with PD. Additionally, further research on sleep and PD is warranted in low- and middle-income countries to ensure the applicability of findings across diverse populations.

Systematic review registration

https://inplasy.com/inplasy-2023-10-0022/, identifier INPLASY2023100022.