Post spike syndrome (PSS): Simple solution leading to resolving results, five cases report.

2026-03-16
IDCases 41
- Roberto S Zeballos
- Mariely Fernanda da Silva Helbingen
- Paulo Macio Porto Melo
- Francisco Eduardo Cardoso Alves
- Caio Roberto Salvino
- Ewerton Paes Seródio
- Edimilson Ramos Migowski de Carvalho

PubMed: 40671933
DOI: 10.1016/j.idcr.2025.e02278

Study Design

Type: Case Report
Population: five patients diagnosed with interstitial granulomatous dermatitis, polymyalgia rheumatica, peripheral polyneuropathy, drug-refractory epilepsy, and trigeminal neuralgia
Methods: This case series includes five patients... A simple therapeutic approach was applied to five patients... A broad intervention including a focus on restoring the microbiome, in particular Bifidobacterium associated with ivermectin and nattokinase was used as a therapeutic strategy. This is an observational and descriptive study, with data collected retrospectively from medical records at a private clinic in São Paulo, Brazil.

Post-Spike Syndrome (PSS) is an emerging condition associated with the Spike protein, originating from both SARS-CoV-2 infection and mRNA-based therapies. This case series explores the significant clinical impact of PSS, characterized By gut dysbiosis, systemic inflammation, and immune activation, leading to multisystem manifestations such as fatigue, brain fog, neuropathies, and reactivation of pre-existing diseases. A simple therapeutic approach was applied to five patients, resulting in notable symptom improvement.

Methods

This case series includes five patients diagnosed with interstitial granulomatous dermatitis, polymyalgia rheumatica, peripheral polyneuropathy, drug-refractory epilepsy, and trigeminal neuralgia. A common pathophysiological mechanism-vasculitis triggered by both SARS-CoV-2 and mRNA-based therapies-was hypothesised. The patients exhibited a satisfactory response to the proposed therapeutic strategy. This is an observational and descriptive study, with data collected retrospectively from medical records at a private clinic in São Paulo, Brazil.

Conclusion

It is crucial to raise awareness within the medical community About SPIKEOPATHY, particularly in cases of classic pathologies that do not respond to conventional treatments. We believe PSS is currently underestimated. A broad intervention including a focus on restoring the microbiome, in particular Bifidobacterium associated with ivermectin and nattokinase was used as a therapeutic strategy. In other studies, Bifidobacterium has already been shown to significantly reduce harmful bactéria in post-COVID patients. Further studies are needed to confirm these findings and expand our understanding of PSS management.

Research Insights

Bifidobacterium bifidum BB-06→Improved Symptoms in Post-Spike Syndrome
A simple therapeutic approach was applied to five patients, resulting in notable symptom improvement... The patients exhibited a satisfactory response to the proposed therapeutic strategy... a focus on restoring the microbiome, in particular Bifidobacterium associated with ivermectin and nattokinase was used as a therapeutic strategy.
Effect
Beneficial
Effect size
Moderate
Bifidobacterium bifidum Bb-02→Improved Symptoms
A broad intervention including a focus on restoring the microbiome, in particular Bifidobacterium associated with ivermectin and nattokinase was used as a therapeutic strategy... The patients exhibited a satisfactory response to the proposed therapeutic strategy.
Effect
Beneficial
Effect size
Moderate
Bifidobacterium lactis BI-04→Improved Gut Microbiome Composition
A broad intervention including a focus on restoring the microbiome, in particular Bifidobacterium... was used as a therapeutic strategy.
Effect
Beneficial
Effect size
Small
Bifidobacterium lactis BI-04→Improved Multisystem Symptoms
The patients exhibited a satisfactory response to the proposed therapeutic strategy.
Effect
Beneficial
Effect size
Moderate
Bifidobacterium lactis Bb-02→Improved Symptoms
A broad intervention including a focus on restoring the microbiome, in particular Bifidobacterium associated with ivermectin and nattokinase was used as a therapeutic strategy... The patients exhibited a satisfactory response to the proposed therapeutic strategy.
Effect
Beneficial
Effect size
Moderate
Bifidobacterium lactis Bi-07→Improved Symptoms
A broad intervention including a focus on restoring the microbiome, in particular Bifidobacterium associated with ivermectin and nattokinase was used as a therapeutic strategy... The patients exhibited a satisfactory response to the proposed therapeutic strategy.
Effect
Beneficial
Effect size
Moderate