Postbiotics against Pathogens Commonly Involved in Pediatric Infectious Diseases.

2020-09-30
Microorganisms 8(10)

PubMed: 33008065
DOI: 10.3390/microorganisms8101510

Study Design

Type: Review
Population: priority populations such as minors under the age of five
Methods: The present review aims to describe the main mechanisms of action of postbiotics. In addition, it presents the available current evidence regarding the effects of postbiotics against pathogens commonly involved in pediatric infections.

The Sustainable Development goals for 2020 included reducing all causes associated with infant and perinatal mortality in their priorities. The use of compounds with bioactive properties has been proposed as a therapeutic strategy due to their stimulating effect on the host's immune system. Additionally, biotherapeutic products such as postbiotics, tentatively defined as compounds produced during a fermentation process that support health and well-being, promote intestinal barrier integrity without posing considerable risks to children's health. Although this is a concept in development, there are increasing studies in the field of nutrition, chemistry, and health that aim to understand how postbiotics can help prevent different types of infections in priority populations such as minors under the age of five. The present review aims to describe the main mechanisms of action of postbiotics. In addition, it presents the available current evidence regarding the effects of postbiotics against pathogens commonly involved in pediatric infections. Postbiotics may constitute a safe alternative capable of modulating the cellular response and stimulating the host's humoral response.

Research Insights

Supplement	Dose	Health Outcome	Effect Type	Effect Size	Source
Lactobacillus rhamnosus	—	Improved Intestinal Barrier Integrity	Beneficial	Moderate	View source postbiotics ... promote intestinal barrier integrity without posing considerable risks to children's health.
Lactobacillus rhamnosus	—	Reduced Risk of Infection	Beneficial	Moderate	View source Postbiotics may constitute a safe alternative capable of modulating the cellular response and stimulating the host's humoral response.