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Potential mechanisms underlying the ameliorative effect of Lactobacillus paracasei FZU103 on the lipid metabolism in hyperlipidemic mice fed a high-fat diet.

  • 2021-01
  • Food Research International 139
    • Xu-Cong Lv
    • Min Chen
    • Zi-Rui Huang
    • Wei-ling Guo
    • Lian-zhong Ai
    • Weidong Bai
    • Xiao-Dan Yu
    • Ying-Li Liu
    • P. Rao
    • Li Ni

Abstract

Lactobacillus paracasei FZU103, a probiotic previously isolated from the traditional brewing process of Hongqu rice wine, may have the beneficial effect of improving the disorder of lipid metabolism. This study aimed to determine the beneficial effects of L. paracasei FZU103 on improving hepatic lipid accumulation associated with hyperlipidemia. Results indicated that L. paracasei FZU103 intervention significantly inhibited the abnormal growth of body weight and epididymal white adipose tissue (eWAT), prevented the hypertrophy of epididymal adipocytes, ameliorated the biochemical parameters of serum and liver related to lipid metabolism in HFD-fed mice. Histological analysis also showed that the excessive accumulation oflipid dropletsin the livers induced by HFD-feeding was greatly alleviated by L. paracasei FZU103 intervention. In addition, L. paracasei FZU103 also promoted the excretion of bile acids (BAs) through feces. Metagenomic analysis revealed that oral supplementation with L. paracasei FZU103 significantly increased the relative abundance of Ruminococcus, Alistipes, Pseudoflavonifractor and Helicobacter, but decreased the levels of Blautia, Staphylococcos and Tannerella in HFD-fed mice. The relationships between lipid metabolic parameters and intestinal microbial phylotypes were also revealed by correlation heatmap and network. Furthermore, ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-QTOF/MS)-based liver metabolomics demonstrated that L. paracasei FZU103 had a significant regulatory effect on the metabolic pathways of glycerophospholipid metabolism, fatty acid degradation, fatty acid elongation, unsaturated fatty acids biosynthesis, riboflavin metabolism, glycerolipid metabolism, primary bile acid biosynthesis, arachidonic acid metabolism, etc. Additionally, L. paracasei FZU103 intervention regulated expression of hepatic genes involved in lipid metabolism and bile acid homeostasis, and promoted fecal excretion of intestinal BAs. These findings present new evidence supporting that L. paracasei FZU103 has the potential to improve lipid metabolism, and could be used as a potential functional food for the prevention of hyperlipidemia.

Keywords: Hyperlipidemia; Intestinal microbiota; Lactobacillus paracasei FZU103; Lipid metabolism; UPLC-QTOF/MS-based liver metabolomics.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactobacillus paracasei 431Altered Gut Microbiota CompositionBeneficial
Moderate
Lactobacillus paracasei 431Improved Lipid MetabolismBeneficial
Large
Lactobacillus paracasei 431Increased Bile Acid ExcretionBeneficial
Moderate
Lactobacillus paracasei 431Reduced Hepatic Fat AccumulationBeneficial
Large
Lactobacillus paracasei 431Reduced Weight GainBeneficial
Large
Lactobacillus paracasei 431Regulated Liver Gene ExpressionBeneficial
Moderate
Lactobacillus paracasei 431Regulated Metabolic PathwaysBeneficial
Large
Lactobacillus paracasei HA-196Improved Liver Metabolic PathwaysBeneficial
Moderate
Lactobacillus paracasei HA-196Increased Bile Acid ExcretionBeneficial
Moderate
Lactobacillus paracasei HA-196Reduced Adipocyte HypertrophyBeneficial
Large
Lactobacillus paracasei HA-196Reduced Hepatic Lipid AccumulationBeneficial
Large
Lactobacillus paracasei HA-196Regulated Intestinal Microbiota CompositionBeneficial
Large
Lactobacillus paracasei HA-196Stable Body WeightBeneficial
Large
Lactobacillus paracasei UALpc-04Improved Gut Microbiome CompositionBeneficial
Large
Lactobacillus paracasei UALpc-04Improved Lipid MetabolismBeneficial
Large
Lactobacillus paracasei UALpc-04Increased Bile Acid ExcretionBeneficial
Moderate
Lactobacillus paracasei UALpc-04Reduced Adipocyte HypertrophyBeneficial
Large
Lactobacillus paracasei UALpc-04Reduced Body WeightBeneficial
Large
Lactobacillus paracasei UALpc-04Reduced Epididymal White Adipose TissueBeneficial
Large
Lactobacillus paracasei UALpc-04Reduced Hepatic Fat AccumulationBeneficial
Large
Lactobacillus paracasei UALpc-04Regulated Liver Gene ExpressionBeneficial
Moderate
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