Potential Modulation of Inflammation by Probiotic and Omega-3 Supplementation in Elderly with Chronic Low-Grade Inflammation-A Randomized, Placebo-Controlled Trial.
- 2022-09-27
- Nutrients 14(19)
- Lina Tingö
- Ashley N Hutchinson
- Cecilia Bergh
- Lena Stiefvatter
- Anna Schweinlin
- Morten G Jensen
- Kirsten Krüger
- Stephan C Bischoff
- Robert J Brummer
- PubMed: 36235651
- DOI: 10.3390/nu14193998
Study Design
- Type
- Randomized Controlled Trial (RCT)
- Population
- 76 community-dwelling elderly participants (median: 71.0 years; IQR: 68.0-73.8)
- Methods
- proof-of-concept, randomized, placebo-controlled, parallel study (NCT04126330), eight weeks of dual supplement (multi-strain probiotic and omega-3) or placebo
- Duration
- eight weeks
- Funding
- Unclear
- Rigorous Journal
Probiotic and omega-3 supplements have been shown to reduce inflammation, and dual supplementation may have synergistic health effects. We investigated if the novel combination of a multi-strain probiotic (containing B. lactis Bi-07, L. paracasei Lpc-37, L. acidophilus NCFM, and B. lactis Bl-04) alongside omega-3 supplements reduces low-grade inflammation as measured by high-sensitivity C-reactive protein (hs-CRP) in elderly participants in a proof-of-concept, randomized, placebo-controlled, parallel study (NCT04126330). In this case, 76 community-dwelling elderly participants (median: 71.0 years; IQR: 68.0-73.8) underwent an intervention with the dual supplement (n = 37) or placebo (n = 39) for eight weeks. In addition to hs-CRP, cytokine levels and intestinal permeability were also assessed at baseline and after the eight-week intervention. No significant difference was seen for hs-CRP between the dual supplement group and placebo. However, interestingly, supplementation did result in significant increases in the level of the anti-inflammatory marker IL-10. In addition, dual supplementation increased levels of valeric acid, further suggesting the potential of the supplements in reducing inflammation and conferring health benefits. Together, the results suggest that probiotic and omega-3 dual supplementation exerts modest effects on inflammation and may have potential use as a non-pharmacological treatment for low-grade inflammation in the elderly.