Prebiotics and Probiotics for Gastrointestinal Disorders.

2024-03-09
Nutrients 16(6)

PubMed: 38542689
DOI: 10.3390/nu16060778

Study Design

Type: Review
Methods: This review aims to summarize the existing evidence for the use of prebiotics and probiotics in various GI disorders, paying special attention to strain-specific effects that emerged and any adverse effects noted.

Rigorous Journal

The complex role of the gut microbiome in the pathogenesis of gastrointestinal (GI) disorders is an emerging area of research, and there is considerable interest in understanding how diet can alter the composition and function of the microbiome. Prebiotics and probiotics have been shown to beneficially modulate the gut microbiome, which underlies their potential for benefit in GI conditions. Formulating specific recommendations for the public regarding these dietary supplements has been difficult due to the significant heterogeneity between strains, doses, and duration of treatment investigated across studies, as well as safety concerns with administering live organisms. This review aims to summarize the existing evidence for the use of prebiotics and probiotics in various GI disorders, paying special attention to strain-specific effects that emerged and any adverse effects noted.

Research Insights

Supplement	Dose	Health Outcome	Effect Type	Effect Size	Source
Bifidobacterium bifidum Rosell-71	—	Reduced Antibiotic-Associated Diarrhea	Beneficial	Moderate	View source Bifidobacterium bifidum Rosell-71, in combination with Lactobacillus acidophilus Rosell-52, was associated with a reduced risk of antibiotic-associated diarrhea in children receiving antibiotics.