Pretransplant Gut Colonization with Intrinsically Vancomycin-Resistant Enterococci (E. gallinarum and E. casseliflavus) and Outcomes of Allogeneic Hematopoietic Cell Transplantation.
- 2018-06
- Biology of Blood and Marrow Transplantation 24(6)
- PubMed: 29407252
- DOI: 10.1016/j.bbmt.2018.01.025
Study Design
- Type
- Observational
- Sample size
- n = 36
- Population
- Patients with and without iVRE colonization
- Methods
- Matched-pairs analysis.
Abstract
Pretransplant gut colonization with intrinsically vancomycin-resistant enterococci (iVRE) (Enterococcus gallinarum and Enterococcus casseliflavus) is uncommon and with unknown clinical impact. In a matched-pairs analysis of patients with versus without iVRE colonization (n = 18 in each group), we demonstrated significantly higher 2-year overall survival (86% [95% confidence interval, 52% to 96%] versus 35% [95% confidence interval, 8% to 65]; P <.01) and lower nonrelapse mortality (P <.01) among colonized patients. Putative metabolomes differentiated iVRE from E. faecalis/faecium and may contribute to a healthier gut microbiome in iVRE-colonized patients.
Keywords: Allogeneic; Biosynthetic; Colonization; Enterococcus; Vancomycin.
Research Insights
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