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Prevention of High-Fat Diet-Induced Hypercholesterolemia by Lactobacillus reuteri Fn041 Through Promoting Cholesterol and Bile Salt Excretion and Intestinal Mucosal Barrier Functions

  • 2022-03-11
  • Frontiers in Nutrition 9
    • Mengyao Lu
    • Jin Sun
    • Yuning Zhao
    • Haowen Zhang
    • Xinyue Li
    • Jingbo Zhou
    • Hongyang Dang
    • Jidong Zhang
    • Wenjing Huang
    • Ce Qi
    • Duo Li


Objectives: Lactobacillus reuteri Fn041 (Fn041) is a probiotic isolated from immunoglobulin A coated microbiota in the human breast milk of Gannan in China with a low incidence of hypercholesterolemia. This study aims to explore the role and mechanism of Fn041 in preventing hypercholesterolemia caused by a high-fat diet in mice.

Methods: C57BL/6N mice were fed a low-fat diet or a high-fat diet and gavage with Fn041 and Lactobacillus rhamnosus GG (LGG) for 8 weeks.

Results: Both Fn041 and LGG prevented the occurrence of hypercholesterolemia, liver and testicular fat accumulation. In addition, a high-fat diet causes intestinal dysbiosis and mucosal barrier damage, which is associated with hypercholesterolemia. Fn041 prevented the high-fat diet-induced reduction in alpha diversity of intestinal microbiota and intestinal mucosal barrier damage. Fn041 treatment significantly increased fecal total cholesterol and total bile acids.

Conclusions: Fn041 prevented hypercholesterolemia by enhancing cholesterol excretion and mucosal barrier function.

Keywords: Lactobacillus reuteri; bile acid; cholesterol; gut microbiota; high-fat diet.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactobacillus reuteriIncreased Cholesterol ExcretionBeneficial
Lactobacillus reuteriPrevention of HypercholesterolemiaBeneficial
Lactobacillus reuteriPrevention of Intestinal DysbiosisBeneficial
Lactobacillus reuteri LRE02Improved Intestinal Mucosal Barrier FunctionBeneficial
Lactobacillus reuteri LRE02Increased Bile Acid ExcretionBeneficial
Lactobacillus reuteri LRE02Increased Cholesterol ExcretionBeneficial
Lactobacillus reuteri LRE02Prevention of Intestinal DysbiosisBeneficial
Lactobacillus reuteri LRE02Reduced Hypercholesterolemia IncidenceBeneficial
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