Prevention of Infectious Mastitis by Oral Administration of Lactobacillus salivarius PS2 During Late Pregnancy.
- 2015-11-26
- Clinical Infectious Diseases 62(5)
- L. Fernández
- Nívia Cárdenas
- Rebeca Arroyo
- S. Manzano
- E. Jiménez
- V. Martín
- J. M. Rodríguez
- PubMed: 26611780
- DOI: 10.1093/cid/civ974
Abstract
Background: Previous studies have shown that oral administration of lactobacilli can be an efficient approach to treat lactational infectious mastitis. In this trial, we have evaluated the potential of Lactobacillus salivarius PS2 to prevent this condition when orally administered during late pregnancy to women who had experienced infectious mastitis after previous pregnancies.
Methods: In this study, 108 pregnant women were randomly assigned to one of 2 groups. Those in the probiotic group (n = 55) ingested daily 9 log10 colony-forming units of L. salivarius PS2 from approximately week 30 of pregnancy until delivery, whereas those in the placebo group (n = 53) received a placebo. The occurrence of mastitis was evaluated during the first 3 months after delivery.
Results: Globally, 44 of 108 women (41%) developed mastitis; however, the percentage of women with mastitis in the probiotic group (25% [n = 14]) was significantly lower than in the control group (57% [n = 30]). When mastitis occurred, the milk bacterial counts in the probiotic group were significantly lower than those obtained in the placebo group.
Conclusions: Oral administration of L. salivarius PS2 during late pregnancy appears to be an efficient method to prevent infectious mastitis in a susceptible population.
Clinical trials registration: NCT01505361.
Keywords: Lactobacillus salivarius; mastitis; pregnancy; prevention; probiotics.
Research Insights
| Supplement | Health Outcome | Effect Type | Effect Size |
|---|---|---|---|
| Lactobacillus Salivarius | Reduced Incidence of Infectious Mastitis | Beneficial | Large |
| Lactobacillus Salivarius | Reduced Milk Bacterial Counts During Mastitis | Beneficial | Moderate |
| Lactobacillus salivarius BLIS K12 | Reduced Milk Bacterial Counts | Beneficial | Moderate |
| Lactobacillus salivarius BLIS K12 | Reduced Occurrence of Mastitis | Beneficial | Moderate |
| Lactobacillus salivarius CRL 1328 | Reduced Incidence of Infectious Mastitis | Beneficial | Large |
| Lactobacillus salivarius CRL 1328 | Reduced Milk Bacterial Counts During Mastitis | Beneficial | Moderate |
| Lactobacillus salivarius HA-118 | Reduced Incidence of Infectious Mastitis | Beneficial | Large |
| Lactobacillus salivarius HA-118 | Reduced Milk Bacterial Counts During Mastitis | Beneficial | Moderate |
| Lactobacillus salivarius SD-5208 | Reduced Incidence of Infectious Mastitis | Beneficial | Large |
| Lactobacillus salivarius SD-5208 | Reduced Milk Bacterial Counts During Mastitis | Beneficial | Moderate |
| Lactobacillus salivarius SD-5851 | Reduced Incidence of Infectious Mastitis | Beneficial | Large |
| Lactobacillus salivarius SD-5851 | Reduced Milk Bacterial Counts During Mastitis | Beneficial | Moderate |
| Lactobacillus salivarius UALb-07 | Reduced Incidence of Infectious Mastitis | Beneficial | Large |
| Lactobacillus salivarius UALb-07 | Reduced Milk Bacterial Counts During Mastitis | Beneficial | Moderate |
| Lactobacillus salivarius UALs07 | Reduced Incidence of Infectious Mastitis | Beneficial | Large |
| Lactobacillus salivarius UALs07 | Reduced Milk Bacterial Counts During Mastitis | Beneficial | Moderate |
| Lactobacillus salivarius UCC118 | Reduced Incidence of Infectious Mastitis | Beneficial | Large |
| Lactobacillus salivarius UCC118 | Reduced Milk Bacterial Counts During Mastitis | Beneficial | Moderate |