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Probiotic and Functional Properties of Limosilactobacillus reuteri INIA P572

  • 2021-05-29
  • Nutrients 13(6)
    • Patricia Diez-Echave
    • Izaskun Martín-Cabrejas
    • J. Garrido-Mesa
    • S. Langa
    • T. Vezza
    • J. Landete
    • Laura Hidalgo-García
    • F. Algieri
    • M. Mayer
    • A. Narbad
    • A. García-Lafuente
    • M. Medina
    • A. Rodríguez‐Nogales
    • M. Rodríguez-Cabezas
    • J. Gálvez
    • J. Arqués


Limosilactobacillus reuteri INIA P572 is a strain able to produce the antimicrobial compound reuterin in dairy products, exhibiting a protective effect against some food-borne pathogens. In this study, we investigated some probiotic properties of this strain such as resistance to gastrointestinal passage or to colonic conditions, reuterin production in a colonic environment, and immunomodulatory activity, using different in vitro and in vivo models. The results showed a high resistance of this strain to gastrointestinal conditions, as well as capacity to grow and produce reuterin in a human colonic model. Although the in vitro assays using the RAW 264.7 macrophage cell line did not demonstrate direct immunomodulatory properties, the in vivo assays using a Dextran Sulphate Sodium (DSS)-induced colitic mice model showed clear immunomodulatory and protective effects of this strain.

Keywords: DSS-induced colitic model; Limosilactobacillus reuteri; colonic model; immunomodulation; probiotic; protective effect; reuterin.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Limosilactobacillus reuteri 1E1Increased Resistance to Gastrointestinal ConditionsBeneficial
Limosilactobacillus reuteri 1E1Increased Reuterin Production in Colonic EnvironmentBeneficial
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