Skip to main content
Supplement Research and Comparison WebsiteBest Price GuaranteeAbout Us
Supplement Research and Comparison Website

Probiotic Lactobacillus paracasei effect on cariogenic bacterial flora

  • 2010-05-26
  • Clinical Oral Investigations 15(4)
    • L. Chuang
    • Chiung-Shing Huang
    • L. Ou-Yang
    • Shiao-Yu Lin

Abstract

Lactobacillus paracasei has been demonstrated to inhibit the growth of many pathogenic microbes such as Streptococcus mutans, in vitro. However, its clinical application remains unclear. Here, we examined whether a novel probiotic L. paracasei GMNL-33 may reduce the caries-associated salivary microbial counts in healthy adults. Seventy-eight subjects (aged 20 to 26) had completed this double-blinded, randomized, placebo-controlled study. A probiotic/test (n = 42) and a control group (n = 36) took a L. paracasei GMNL-33 and a placebo oral tablet three times per day for 2 weeks, respectively. Bacterial counts of salivary S. mutans, lactobacilli, and salivary buffer capacity were measured with chair-side kits at the beginning (T1), the completion (T2) of medication, and 2 weeks after medication (T3). The results did not show differences in the counts of S. mutans and lactobacilli between probiotic and control groups at T1, T2, and T3. Nevertheless, within the probiotic group, an interesting probiotic effect was noticed. Between T1 and T2, no inhibitory effect against S. mutans was observed. However, a significant count reduction in the salivary S. mutans was detected between T2 and T3 (p = 0.016). Thus, a 2-week period of medication via oral administration route may be needed for L. paracasei GMNL-33 to be effective in the probiotic action.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactobacillus paracaseiReduced Salivary S. mutans CountBeneficial
Moderate
Lactobacillus paracasei 431Reduced Streptococcus Mutans LevelsBeneficial
Moderate
Lactobacillus paracasei DSM 13434Reduced Salivary Levels of Mutans StreptococciBeneficial
Moderate
Lactobacillus paracasei LPC09Reduced Salivary S. mutans CountBeneficial
Moderate
Lactobacillus paracasei subsp. paracasei UALpc-04Reduced Salivary S. mutans CountBeneficial
Moderate
Lactobacillus paracasei subsp. paracasei UALs-04Reduced Mutans Streptococcus CountsBeneficial
Moderate
Lactobacillus paracasei UALpc-04Reduced Salivary Levels of Mutans StreptococciBeneficial
Moderate
Lactobacillus paracasei VPro 224Reduced Salivary Levels of Mutans StreptococciBeneficial
Moderate
⬆ Back to top
Unsubscribe anytime. See our Privacy Policy.
Pillser
Supplement Research and Comparison Website: evidence-based information about supplements, their benefits, potential risks, and their efficacy.

Join Our Community

Statements on this website have not been reviewed by the U.S. Food and Drug Administration. These products are not meant to diagnose, treat, cure, or prevent any disease. The information here is not a replacement for personal medical advice.