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Probiotic Lactobacillus rhamnosus GG and Aloe vera gel improve lipid profiles in hypercholesterolemic rats.

  • 2013-03
  • Nutrition 29(3)
    • Manoj Kumar
    • S. Rakesh
    • R. Nagpal
    • R. Hemalatha
    • A. Ramakrishna
    • V. Sudarshan
    • Ramesh Ramagoni
    • Mohd. Shujauddin
    • V. Verma
    • Ashok Kumar
    • A. Tiwari
    • Birbal Singh
    • R. Kumar


Objective: The effects of Lactobacillus rhamnosus GG (LGG) and Aloe vera (AV) gel on lipid profiles in rats with induced hypercholesterolemia were studied.

Methods: Five treatment groups of rats (n = 7) were the fed experimental diets: a normal control diet, a hypercholesterolemic diet (HD), HD + LGG, HD + AV gel, and HD + LGG + AV gel.

Results: Supplementation with LGG decreased serum total cholesterol by 32%; however, in combination with AV, the decrease was 43%. The decreases in triacylglycerol levels in the HD + LGG, HD + AV, and HD + LGG + AV groups were 41%, 23% and 45%, respectively. High-density lipoprotein increased by 12% in the HD + LGG + AV group, whereas very low-density and low-density lipoprotein values decreased by 45% and 30%, respectively. The atherogenic index in the HD + LGG + AV group decreased to 2.45 from 4.77 in the HD + LGG group. Furthermore, fecal Lactobacillus species counts increased significantly when LGG was fed in combination with the AV gel. The oral administration of LGG fermented milk alone or in combination with the AV gel increased cholesterol synthesis (3-hydroxy-3-methylglutaryl coenzyme A reductase expression) and absorption (low-density lipoprotein receptor expression), whereas cholesterol 7α-hydroxylase mRNA expression levels were lower in the HD + LGG and HD + LGG + AV groups compared with the control HD group.

Conclusion: The combination of LGG and AV gel may have a therapeutic potential to decrease cholesterol levels and the risk of cardiovascular diseases.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactobacillus rhamnosus Lr-32Maintained High-Density Lipoprotein LevelsBeneficial
Lactobacillus rhamnosus Lr-32Reduced Atherogenic IndexBeneficial
Lactobacillus rhamnosus Lr-32Reduced Cholesterol MetabolismNeutral
Lactobacillus rhamnosus Lr-32Reduced Serum Total CholesterolBeneficial
Lactobacillus rhamnosus Lr-32Reduced Serum TriacylglycerolsBeneficial
Lactobacillus rhamnosus Lr-32Reduced Very Low-Density LipoproteinBeneficial
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