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Probiotic Strain Bifidobacterium animalis subsp. lactis CECT 8145 Reduces Fat Content and Modulates Lipid Metabolism and Antioxidant Response in Caenorhabditis elegans.

  • 2016-04-19
  • Journal of Agricultural and Food Chemistry 64(17)
    • P. Martorell
    • S. Llopis
    • Núria González
    • E. Chenoll
    • Noemi López-Carreras
    • A. Aleixandre
    • Yang Chen
    • Edwuard D Karoly
    • D. Ramón
    • S. Genovés

Abstract

Recently, microbial changes in the human gut have been proposed as a possible cause of obesity. Therefore, modulation of microbiota through probiotic supplements is of great interest to support obesity therapeutics. The present study examines the functional effect and metabolic targets of a bacterial strain, Bifidobacterium animalis subsp. lactis CECT 8145, selected from a screening in Caenorhabditis elegans. This strain significantly reduced total lipids (40.5% ± 2.4) and triglycerides (27.6% ± 0.5), exerting antioxidant effects in the nematode (30% ± 2.8 increase in survival vs control); activities were also preserved in a final food matrix (milk). Furthermore, transcriptomic and metabolomic analyses in nematodes fed with strain CECT 8145 revealed modulation of the energy and lipid metabolism, as well as the tryptophan metabolism (satiety), as the main metabolic targets of the probiotic. In conclusion, our study describes for the first time a new B. animalis subsp. lactis strain, CECT 8145, as a promising probiotic for obesity disorders. Furthermore, the data support future studies in obesity murine models.

Keywords: Bifidobacterium strain; Caenorhabditis elegans; metabolic syndrome; obesity; probiotic.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Bifidobacterium animalis subsp. lactisEnhanced Antioxidant ResponseBeneficial
Moderate
Bifidobacterium animalis subsp. lactisReduced Total Lipid LevelsBeneficial
Large
Bifidobacterium animalis subsp. lactisReduced Triglyceride LevelsBeneficial
Large
Bifidobacterium animalis subsp. lactisRegulated Tryptophan MetabolismBeneficial
Moderate
Bifidobacterium animalis subsp. lactis B420Enhanced Antioxidant ResponseBeneficial
Moderate
Bifidobacterium animalis subsp. lactis B420Improved Blood Lipid MetabolismBeneficial
Moderate
Bifidobacterium animalis subsp. lactis B420Improved Satiety ResponseBeneficial
Moderate
Bifidobacterium animalis subsp. lactis B420Reduced Lipid LevelsBeneficial
Large
Bifidobacterium animalis subsp. lactis B420Reduced Triglyceride LevelsBeneficial
Large
Bifidobacterium animalis subsp. lactis CECT 8145Enhanced Antioxidant DefenseBeneficial
Moderate
Bifidobacterium animalis subsp. lactis CECT 8145Reduced Lipid LevelsBeneficial
Large
Bifidobacterium animalis subsp. lactis CECT 8145Reduced Triglyceride LevelsBeneficial
Large
Bifidobacterium animalis subsp. lactis CECT 8145Regulated Tryptophan MetabolismBeneficial
Moderate
Bifidobacterium animalis subsp. lactis VK2Enhanced Antioxidant Enzyme ActivityBeneficial
Moderate
Bifidobacterium animalis subsp. lactis VK2Reduced Total Lipid LevelsBeneficial
Large
Bifidobacterium animalis subsp. lactis VK2Reduced Triglyceride LevelsBeneficial
Large
Bifidobacterium animalis subsp. lactis VK2Regulated Tryptophan MetabolismBeneficial
Moderate
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