Probiotics and Alcoholic Liver Disease: Treatment and Potential Mechanisms.

2016
Gastroenterology research and practice 2016

PubMed: 26839540
DOI: 10.1155/2016/5491465

Study Design

Type: Review
Methods: We summarize recent studies on probiotic intervention in the prevention and treatment of ALD in experimental animal models and patients.

Despite extensive research, alcohol remains one of the most common causes of liver disease in the United States. Alcoholic liver disease (ALD) encompasses a broad spectrum of disorders, including steatosis, steatohepatitis, and cirrhosis. Although many agents and approaches have been tested in patients with ALD and in animals with experimental ALD in the past, there is still no FDA (Food and Drug Administration) approved therapy for any stage of ALD. With the increasing recognition of the importance of gut microbiota in the onset and development of a variety of diseases, the potential use of probiotics in ALD is receiving increasing investigative and clinical attention. In this review, we summarize recent studies on probiotic intervention in the prevention and treatment of ALD in experimental animal models and patients. Potential mechanisms underlying the probiotic function are also discussed.

Research Insights

Supplement	Dose	Health Outcome	Effect Type	Effect Size	Source
Lactobacillus brevis SBC8803	—	Improvement in Alcoholic Liver Disease	Beneficial	Moderate	View source the potential use of probiotics in ALD is receiving increasing investigative and clinical attention. In this review, we summarize recent studies on probiotic intervention in the prevention and treatment of ALD in experimental animal models and patients.
Lactobacillus brevis SBC8803	—	Reduced Disease Severity	Beneficial	Moderate	View source the potential use of probiotics in ALD is receiving increasing investigative and clinical attention. In this review, we summarize recent studies on probiotic intervention in the prevention and treatment of ALD in experimental animal models and patients.