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Probiotics and Prebiotics Orally Assumed as Disease Modifiers for Stable Mild Atopic Dermatitis: An Italian Real-Life, Multicenter, Retrospective, Observational Study.

  • 2023-11-27
  • Medicina (Kaunas, Lithuania) 59(12)
    • Delia Colombo
    • Corinna Rigoni
    • Alessandra Cantù
    • Antonello Carnevali
    • Rossella Filippetti
    • Tiziana Franco
    • Alessandra Grassi
    • Camilla Loi
    • Annamaria Mazzotta
    • Ivona Patroi
    • Beatrice Raone
    • Marco Andrea Tomassini
    • Angela Amoruso
    • Marco Pane
    • Giovanni Damiani

Study Design

Type
Observational
Population
144 enrolled patients (average age: 25.1 ± 17.6 years) with mild atopic dermatitis
Methods
real-life, multicenter, retrospective observational study in Italy; three selected bacteria (Bifidobacterium animalis subsp. lactis BS01, Lactiplantibacillus plantarum LP14, and Lacticaseibacillus rhamnosus LR05) administered orally
Duration
12 weeks
Funding
Unclear
The role of the skin-gut axis in atopic dermatitis (AD) remains a subject of debate, limiting non-pharmacological interventions such as probiotics and prebiotics. To improve understanding of their potential as a monotherapy for stable mild cases, we conducted a real-life, multicenter, retrospective observational study in Italy. We administered three selected bacteria (Bifidobacterium animalis subsp. lactis BS01, Lactiplantibacillus plantarum LP14, and Lacticaseibacillus rhamnosus LR05) orally to patients with mild atopic dermatitis without a placebo control group, following up for 12 weeks. Clinical assessments using the Scoring Atopic Dermatitis (SCORAD), Eczema Area and Severity Index (EASI), and Three-Item Severity (TIS) score were conducted on 144 enrolled patients (average age: 25.1 ± 17.6 years). Notably, both pruritus and AD-related lesions (erythema, edema/papules, excoriation) exhibited significant clinical and statistical improvement (p < 0.001) after 12 weeks of exclusive probiotic and prebiotic use. These preliminary results suggest a potential link between the skin-gut microbiome and support the rationale for using specific probiotics and prebiotics in mild AD, even for maintenance, to reduce flares and dysbiosis.

Research Insights

  • Bifidobacterium lactis BS01→Reduced Eczema Severity

    Notably, both pruritus and AD-related lesions (erythema, edema/papules, excoriation) exhibited significant clinical and statistical improvement (p < 0.001) after 12 weeks of exclusive probiotic and prebiotic use.

    Effect
    Beneficial
    Effect size
    Moderate
    Dose
    Not stated
  • Bifidobacterium lactis BS01→Reduced Pruritus

    Notably, both pruritus and AD-related lesions (erythema, edema/papules, excoriation) exhibited significant clinical and statistical improvement (p < 0.001) after 12 weeks of exclusive probiotic and prebiotic use.

    Effect
    Beneficial
    Effect size
    Moderate
    Dose
    Not stated
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