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Probiotics diminish the post-operatory pain following mandibular third molar extraction: a randomised double-blind controlled trial (pilot study).

  • 2020-11-15
  • Beneficial Microbes 11(7)
    • E. Ferrés-Amat
    • Jordi Espadaler Mazo
    • J. Calvo-Guirado
    • E. Ferrés-Amat
    • J. Mareque-Bueno
    • A. Salavert
    • M. Aguiló-García
    • J. Moreno-Centeno
    • E. Ferrés-Padró


The aim of this study was to investigate the effect of a probiotic in preventing infections after third molar surgery. Thirty-eight patients were consecutively enrolled to a double-blind randomised placebo-controlled trial. Patients were asked to take one tablet two times a day containing a mixture of Levilactobacillus brevis CECT7480 (KABP-052) and Lactoplantibacillus plantarum CECT7481 (KABP-051) or placebo for the first post-intervention week. The primary outcome was the postoperative infection rate. Secondary outcomes included swelling, eating difficulties and postoperative pain recorded by the patient using a visual analogue scale (VAS) during the first postoperative week. No statistically significant difference in the infection rate between the groups was found; with only three cases of infections reported (one in the probiotic group and two in the placebo group) on the first week. Compared to placebo, treatment with the probiotic showed a significantly higher reduction in pain and eating difficulties scores at 5, 6 and 7 days post-surgery. Swelling values were not significantly different between the groups at any time point. The findings of this pilot study justify a larger study to clarify the possible role of these bacterial strains on the post-operative pain management following third molar surgery.

Keywords: GABA; alveolar osteitis; lactobacilli; oral surgery.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactobacillus brevis KABP™-052Reduced Eating DifficultiesBeneficial
Lactobacillus brevis KABP™-052Reduced Postoperative PainBeneficial
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