Probiotics diminish the post-operatory pain following mandibular third molar extraction: a randomised double-blind controlled trial (pilot study).
- 2020-11-15
- Beneficial Microbes 11(7)
- E. Ferrés-Amat
- Jordi Espadaler Mazo
- J. Calvo-Guirado
- E. Ferrés-Amat
- J. Mareque-Bueno
- A. Salavert
- M. Aguiló-García
- J. Moreno-Centeno
- E. Ferrés-Padró
- PubMed: 33124895
- DOI: 10.3920/BM2020.0090
Abstract
The aim of this study was to investigate the effect of a probiotic in preventing infections after third molar surgery. Thirty-eight patients were consecutively enrolled to a double-blind randomised placebo-controlled trial. Patients were asked to take one tablet two times a day containing a mixture of Levilactobacillus brevis CECT7480 (KABP-052) and Lactoplantibacillus plantarum CECT7481 (KABP-051) or placebo for the first post-intervention week. The primary outcome was the postoperative infection rate. Secondary outcomes included swelling, eating difficulties and postoperative pain recorded by the patient using a visual analogue scale (VAS) during the first postoperative week. No statistically significant difference in the infection rate between the groups was found; with only three cases of infections reported (one in the probiotic group and two in the placebo group) on the first week. Compared to placebo, treatment with the probiotic showed a significantly higher reduction in pain and eating difficulties scores at 5, 6 and 7 days post-surgery. Swelling values were not significantly different between the groups at any time point. The findings of this pilot study justify a larger study to clarify the possible role of these bacterial strains on the post-operative pain management following third molar surgery.
Keywords: GABA; alveolar osteitis; lactobacilli; oral surgery.
Research Insights
Supplement | Health Outcome | Effect Type | Effect Size |
---|---|---|---|
Lactobacillus brevis KABP™-052 | Reduced Eating Difficulties | Beneficial | Moderate |
Lactobacillus brevis KABP™-052 | Reduced Postoperative Pain | Beneficial | Moderate |