Probiotics in Orthopedics: From Preclinical Studies to Current Applications and Future Perspective.

2023-08-06
Microorganisms 11(8)

PubMed: 37630580
DOI: 10.3390/microorganisms11082021

Study Design

Type: Review

In recent years, probiotics have been emerging as an attractive therapeutic strategy for several diseases. In orthopedics, probiotics seem to be a promising supplementation for treatment of osteoporosis, osteoarthritis, muscle loss-related disease, wound and ulcer issues, and prevention of surgical antibiotic prophylaxis side effects. Although probiotics are still not included in guidelines for these conditions, several studies have reported theoretical benefits of their administration. Further high-level clinical trials are necessary to convert research into solid clinical practice. However, probiotics represent a cost-effective future perspective and may play a role in association with traditional orthopedic therapies.

Research Insights

Supplement	Dose	Health Outcome	Effect Type	Effect Size	Source
Bifidobacterium bifidum UABb-10	—	Improved Orthopedic Function	Beneficial	Small	View source probiotics seem to be a promising supplementation for treatment of osteoporosis, osteoarthritis, muscle loss-related disease, wound and ulcer issues, and prevention of surgical antibiotic prophylaxis side effects
Bifidobacterium longum UABl-14	—	Improved Gut Microbiota Composition	Beneficial	Small	View source Several studies have reported theoretical benefits of their administration. Further high-level clinical trials are necessary to convert research into solid clinical practice.