[Probiotics' position in clinical practice: focus on the combination of Lactobacillus acidophilus (LA-5) and Bifidobacterium animalis subsp. lactis (BB-12). A review].

2026-02-14
Terapevticheskii arkhiv 97(12)
- A V Gorelov
- R S Kozlov
- I V Andreeva
- A A Arova
- I A Bavykina
- M S Grigorovich
- E V Dovgan
- K D Ermolenko
- O V Zaytseva
- S M Zakharenko
- V V Zelenskaia
- S K Zyryanov
- N A Ilyenkova
- M A Kachkovskii
- T A Kogut
- E G Kondyurina
- V V Krasnov
- E E Lokshina
- V F Privorotsky
- M N Repetskaya
- M F Rzyankina
- S N Serikova
- O U Stetsiouk
- D V Usenko
- L V Khanipova
- A M Shabalov
- M A Shevyakov
- L V Yakovleva

PubMed: 41705617
DOI: 10.26442/00403660.2025.12.203481

Study Design

Type: Review
Methods: The purpose of our review is to highlight what we consider to be the most significant clinical studies on the use of probiotics for preventing antibiotic-associated diarrhea, clostridial diarrhea and pseudomembranous colitis. The article also presents the results of studies confirming the efficacy of probiotics in Helicobacter pylori eradication therapy. The review focuses on Linex® Forte, medicinal product containing the combination of Lactobacillus acidophilus (LA-5) and Bifidobacterium animalis subsp. lactis (BB-12).

Probiotics are currently widely used in clinical practice to prevent and treat a wide range of diseases. The purpose of our review is to highlight what we consider to be the most significant clinical studies on the use of probiotics for preventing antibiotic-associated diarrhea, clostridial diarrhea and pseudomembranous colitis. The article also presents the results of studies confirming the efficacy of probiotics in Helicobacter pylori eradication therapy. The review focuses on Linex^® Forte, medicinal product containing the combination of Lactobacillus acidophilus (LA-5) and Bifidobacterium animalis subsp.lactis (BB-12).

Research Insights

Bifidobacterium animalis subsp. lactis BB-12→Increased Helicobacter pylori Eradication Rate
The article also presents the results of studies confirming the efficacy of probiotics in Helicobacter pylori eradication therapy.
Effect
Beneficial
Effect size
Small
Bifidobacterium animalis subsp. lactis BB-12→Reduced Antibiotic-Associated Diarrhea
The purpose of our review is to highlight what we consider to be the most significant clinical studies on the use of probiotics for preventing antibiotic-associated diarrhea...
Effect
Beneficial
Effect size
Moderate