Probiotics, Prebiotics, Synbiotics, and Paraprobiotics as a Therapeutic Alternative for Intestinal Mucositis.
- 2020-09-17
- Frontiers in microbiology 11
- Viviane Lima Batista
- Tales Fernando da Silva
- Luís Cláudio Lima de Jesus
- Nina Dias Coelho-Rocha
- Fernanda Alvarenga Lima Barroso
- Laisa Macedo Tavares
- Vasco Azevedo
- Pamela Mancha-Agresti
- Mariana Martins Drumond
- PubMed: 33042054
- DOI: 10.3389/fmicb.2020.544490
Study Design
- Type
- Review
Intestinal mucositis, a cytotoxic side effect of the antineoplastic drug 5-fluorouracil (5-FU), is characterized by ulceration, inflammation, diarrhea, and intense abdominal pain, making it an important issue for clinical medicine. Given the seriousness of the problem, therapeutic alternatives have been sought as a means to ameliorate, prevent, and treat this condition. Among the alternatives available to address this side effect of treatment with 5-FU, the most promising has been the use of probiotics, prebiotics, synbiotics, and paraprobiotics. This review addresses the administration of these "biotics" as a therapeutic alternative for intestinal mucositis caused by 5-FU. It describes the effects and benefits related to their use as well as their potential for patient care.