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Prophylactic Effects of Bifidobacterium adolescentis on Anxiety and Depression-Like Phenotypes After Chronic Stress: A Role of the Gut Microbiota-Inflammation Axis

  • 2019-06-18
  • Frontiers in Behavioral Neuroscience 13
    • Ying Guo
    • Jianping Xie
    • Ke Deng
    • Xia Li
    • Yun Yuan
    • Qun Xuan
    • Jing Xie
    • Xiao-Ming He
    • Qian Wang
    • Juan-Juan Li
    • Huai-Rong Luo


Stress disturbs the balance of the gut microbiota and stimulates inflammation-to-brain mechanisms. Moreover, stress leads to anxiety and depressive disorders. Bifidobacterium adolescentis displays distinct anti-inflammatory effects. However, no report has focused on the anxiolytic and antidepressant effects of B. adolescentis related to the gut microbiome and the inflammation on chronic restraint stress (CRS) in mice. We found that pretreatment with B. adolescentis increased the time spent in the center of the open field apparatus, increased the percentage of entries into the open arms of the elevated plus-maze (EPM) and the percentage of time spent in the open arms of the EPM, and decreased the immobility duration in the tail suspension test as well as the forced swimming test (FST). Moreover, B. adolescentis increased the sequence proportion of Lactobacillus and reduced the sequence proportion of Bacteroides in feces. Furthermore, B. adolescentis markedly reduced the protein expression of interleukin-1β (IL-1β), tumor necrosis factor α (TNF-α), p-nuclear factor-kappa B (NF-κB) p65 and Iba1 and elevated brain derived neurotrophic factor (BDNF) expression in the hippocampus. We conclude that the anxiolytic and antidepressant effects of B. adolescentis are related to reducing inflammatory cytokines and rebalancing the gut microbiota.

Keywords: Bifidobacterium adolescentis; antidepressant; chronic restraint stress; gut microbiota; inflammation.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Bifidobacterium adolescentisEnhanced Brain-Derived Neurotrophic Factor LevelsBeneficial
Bifidobacterium adolescentisImproved Gut Microbiome CompositionBeneficial
Bifidobacterium adolescentisReduced Anxiety LevelsBeneficial
Bifidobacterium adolescentisReduced Depression SymptomsBeneficial
Bifidobacterium adolescentisReduced Inflammation LevelsBeneficial
Bifidobacterium adolescentis iVS-1Balanced Gut MicrobiotaBeneficial
Bifidobacterium adolescentis iVS-1Reduced AnxietyBeneficial
Bifidobacterium adolescentis iVS-1Reduced Depression SymptomsBeneficial
Bifidobacterium adolescentis iVS-1Reduced Inflammatory Cytokine LevelsBeneficial
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