Prostate cancer chemoprevention by natural agents: Clinical evidence and potential implications.

2018-05
Cancer letters 422
- Gagan Chhabra
- Chandra K Singh
- Mary Ann Ndiaye
- Samantha Fedorowicz
- Arielle Molot
- Nihal Ahmad

PubMed: 29471004
DOI: 10.1016/j.canlet.2018.02.025

Study Design

Type: Review

Prostate cancer (PCa) is the most common non-skin cancer and the second leading cause of cancer-related deaths in American men. Due to its long latency period, PCa is considered as an ideal cancer type for chemopreventive interventions. Chemopreventive agents include various natural or synthetic agents that prevent or delay cancer development, progression and/or recurrence. Pre-clinical studies suggest that many natural products and dietary agents have chemopreventive properties. However, a limited number of these agents have been tested in clinical trials, with varying success. In this review, we have discussed the available clinical studies regarding the efficacy of natural chemopreventive agents against PCa, including tea polyphenols, selenium, soy proteins, vitamins and resveratrol. We have also provided a discussion on the clinical challenges and opportunities for the potential use of chemopreventive agents against PCa. Based on available literature, it appears that the variable outcomes of the chemopreventive clinical studies necessitate a need for additional studies with more rigorous designs and methodical interpretations in order to measure the potential of the natural agents against PCa.

Research Insights

Green Tea→Reduced Prostate Cancer Risk
we have discussed the available clinical studies regarding the efficacy of natural chemopreventive agents against PCa, including tea polyphenols, selenium, soy proteins, vitamins and resveratrol... the variable outcomes of the chemopreventive clinical studies
Effect
Neutral
Effect size
Small
Resveratrol→Reduced Prostate Cancer Risk
we have discussed the available clinical studies regarding the efficacy of natural chemopreventive agents against PCa, including tea polyphenols, selenium, soy proteins, vitamins and resveratrol... the variable outcomes of the chemopreventive clinical studies
Effect
Neutral
Effect size
Small
Selenium→Reduced Prostate Cancer Risk
we have discussed the available clinical studies regarding the efficacy of natural chemopreventive agents against PCa, including tea polyphenols, selenium, soy proteins, vitamins and resveratrol... the variable outcomes of the chemopreventive clinical studies
Effect
Neutral
Effect size
Small