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Protective effects of probiotic Lactobacillus rhamnosus IMC501 in mice treated with PhIP.

  • 2014-03-28
  • Journal of Microbiology and Biotechnology 24(3)
    • L. Dominici
    • M. Villarini
    • F. Trotta
    • E. Federici
    • G. Cenci
    • M. Moretti

Abstract

The aim of the present study was to investigate the antigenotoxic properties of the probiotic Lactobacillus rhamnosus IMC501; DNA damage was induced by one representative food mutagen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). Mice were treated orally with suspensions of lactobacilli for 10 days before administration of food mutagen. During the treatment, the abundance of lactobacilli in feces, as assessed by qPCR analysis, increased, whereas β-glucuronidase and N-acetyl-β-glucosaminidase activities decreased. The extent of DNA damage was measured in colon and liver cells by comet assay. In colonocytes, diet supplementation with IMC501 resulted in a significant inhibition of DNA damage induced by PhIP. The results obtained in this in vitro study suggest that Lactobacillus rhamnosus IMC501 used as a dietary supplement can provide a useful integration of antimutagen food components of the normal diet, which are generally lower than the protective level.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactobacillus rhamnosus IMC 501Increased Fecal Lactobacilli AbundanceBeneficial
Moderate
Lactobacillus rhamnosus IMC 501Reduced Beta-Glucuronidase ActivityBeneficial
Moderate
Lactobacillus rhamnosus IMC 501Reduced DNA DamageBeneficial
Moderate
Lactobacillus rhamnosus IMC 501Reduced N-acetyl-β-glucosaminidase ActivityBeneficial
Moderate
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