- 2024-01-16
- BMC infectious diseases 24(1)
- Xidong Wang
- Shaoqiang Li
- Mangui Zhu
- Ye Qiu
- Yilei Hui
- Yongming Li
- Yangqing Zhan
- Yan Wang
- Feng Ye
- Zhengtu Li
Study Design
- Type
- Systematic Review
- Population
- Patients with pulmonary cryptococcosis complicated with pulmonary aspergillosis (11 patients total: 5 from retrospective study, 6 from systematic literature review)
- Methods
- A retrospective study from 2014 to 2022 and a systematic literature review of original articles published in English were performed.
Background/objective
With the development of society, pulmonary fungal diseases, represented by pulmonary aspergillosis and pulmonary cryptococcosis, have become increasingly common. However, there is a lack of clear understanding regarding coinfection by these two types of fungi in immunocompetent individuals.Methods
A retrospective study from 2014 to 2022 and a systematic literature review of original articles published in English were performed. Patients with pulmonary cryptococcosis complicated with pulmonary aspergillosis including 5 in the retrospective study and 6 in the systematic literature review.Result
The diagnosis of concurrent pulmonary cryptococcosis and pulmonary aspergillosis in patients was confirmed through repeated biopsies or surgical resection. Pulmonary cryptococcosis is often diagnosed initially (6/11, 55%), while the diagnosis of pulmonary aspergillosis is established when the lesions become fixed or enlarged during treatment. Transbronchial lung biopsy (3/11, 27%), thoracoscopic lung biopsy (2/11, 18%), and percutaneous aspiration biopsy of the lung (1/11, 9%) were the main methods to confirm concurrent infection. Most patients were treated with voriconazole, resulting in a cure for the coinfection (6/11, 55%).Conclusion
Pulmonary cryptococcosis complicated with pulmonary Aspergillus is an easily neglected mixed fungal infection. During the treatment of lesion enlargement in clinical cryptococcus, we need to watch out for Aspergillus infection.