Recent Advances in Poly(α-L-glutamic acid)-Based Nanomaterials for Drug Delivery.
- 2022-04-25
- Biomolecules 12(5)
- Yu Zhang
- Wenliang Song
- Yiming Lu
- Yixin Xu
- Changping Wang
- Deng-Guang Yu
- Il Kim
- PubMed: 35625562
- DOI: 10.3390/biom12050636
Study Design
- Type
- Review
Poly(α-L-glutamic acid) (PGA) is a class of synthetic polypeptides composed of the monomeric unit α-L-glutamic acid. Owing to their biocompatibility, biodegradability, and non-immunogenicity, PGA-based nanomaterials have been elaborately designed for drug delivery systems. Relevant studies including the latest research results on PGA-based nanomaterials for drug delivery have been discussed in this work. The following related topics are summarized as: (1) a brief description of the synthetic strategies of PGAs; (2) an elaborated presentation of the evolving applications of PGA in the areas of drug delivery, including the rational design, precise fabrication, and biological evaluation; (3) a profound discussion on the further development of PGA-based nanomaterials in drug delivery. In summary, the unique structures and superior properties enables PGA-based nanomaterials to represent as an enormous potential in biomaterials-related drug delivery areas.