Recent Advances in Synthetic Drugs and Natural Actives Interacting with OAT3.
- 2023-06-13
- Molecules (Basel, Switzerland) 28(12)
- Ying Chen
- Hongyan Li
- Ke Wang
- Yousheng Wang
- PubMed: 37375294
- DOI: 10.3390/molecules28124740
Study Design
- Type
- Review
Organic anion transporter 3 (OAT3) is predominantly expressed in the kidney and plays a vital role in drug clearance. Consequently, co-ingestion of two OAT3 substrates may alter the pharmacokinetics of the substrate. This review summarizes drug-drug interactions (DDIs) and herbal-drug interactions (HDIs) mediated by OAT3, and inhibitors of OAT3 in natural active compounds in the past decade. This provides a valuable reference for the combined use of substrate drugs/herbs for OAT3 in clinical practice in the future and for the screening of OAT3 inhibitors to avoid harmful interactions.