Regulation of abdominal adiposity by probiotics (Lactobacillus gasseri SBT2055) in adults with obese tendencies in a randomized controlled trial
- 2010-03-10
- European Journal of Clinical Nutrition 64(6)
- Y. Kadooka
- M. Sato
- K. Imaizumi
- A. Ogawa
- Ken Ikuyama
- Y. Akai
- M. Okano
- M. Kagoshima
- T. Tsuchida
- PubMed: 20216555
- DOI: 10.1038/ejcn.2010.19
Abstract
Background/objectives: In spite of the much evidence for the beneficial effects of probiotics, their anti-obesity effects have not been well examined. We evaluated the effects of the probiotic Lactobacillus gasseri SBT2055 (LG2055) on abdominal adiposity, body weight and other body measures in adults with obese tendencies.
Subjects/methods: We conducted a multicenter, double-blind, randomized, placebo-controlled intervention trial. Subjects (n=87) with higher body mass index (BMI) (24.2-30.7 kg/m(2)) and abdominal visceral fat area (81.2-178.5 cm(2)) were randomly assigned to receive either fermented milk (FM) containing LG2055 (active FM; n=43) or FM without LG2055 (control FM; n=44), and were asked to consume 200 g/day of FM for 12 weeks. Abdominal fat area was determined by computed tomography.
Results: In the active FM group, abdominal visceral and subcutaneous fat areas significantly (P<0.01) decreased from baseline by an average of 4.6% (mean (confidence interval): -5.8 (-10.0, -1.7) cm(2)) and 3.3% (-7.4 (-11.6, -3.1) cm(2)), respectively. Body weight and other measures also decreased significantly (P<0.001) as follows: body weight, 1.4% (-1.1 (-1.5, -0.7) kg); BMI, 1.5% (-0.4 (-0.5, -0.2) kg/m(2)); waist, 1.8% (-1.7 (-2.1, -1.4) cm); hip, 1.5% (-1.5 (-1.8, -1.1) cm). In the control group, by contrast, none of these parameters decreased significantly. High-molecular weight adiponectin in serum increased significantly (P<0.01) in the active and control groups by 12.7% (0.17 (0.07, 0.26) microg/ml) and 13.6% (0.23 (0.07, 0.38) microg/ml), respectively.
Conclusion: The probiotic LG2055 showed lowering effects on abdominal adiposity, body weight and other measures, suggesting its beneficial influence on metabolic disorders.
Research Insights
| Supplement | Health Outcome | Effect Type | Effect Size |
|---|---|---|---|
| Lactobacillus gasseri | Increased Adiponectin Levels | Beneficial | Small |
| Lactobacillus gasseri | Reduced Abdominal Visceral Fat Area | Beneficial | Moderate |
| Lactobacillus gasseri | Reduced Body Weight | Beneficial | Small |
| Lactobacillus gasseri | Reduced Waist Circumference | Beneficial | Small |
| Lactobacillus gasseri BNR17 | Increased Adiponectin Levels | Beneficial | Small |
| Lactobacillus gasseri BNR17 | Reduced Body Weight | Beneficial | Small |
| Lactobacillus gasseri BNR17 | Reduced Visceral Fat Mass | Beneficial | Moderate |
| Lactobacillus gasseri KS-13 | Increased Serum High-Molecular Weight Adiponectin | Beneficial | Moderate |
| Lactobacillus gasseri KS-13 | Reduced Abdominal Fat | Beneficial | Moderate |
| Lactobacillus gasseri KS-13 | Reduced Body Mass Index | Beneficial | Small |
| Lactobacillus gasseri KS-13 | Reduced Body Weight | Beneficial | Small |
| Lactobacillus gasseri KS-13 | Reduced Hip Circumference | Beneficial | Small |
| Lactobacillus gasseri KS-13 | Reduced Waist Circumference | Beneficial | Small |
| Lactobacillus gasseri LAC-343 | Increased Adiponectin Levels | Beneficial | Small |
| Lactobacillus gasseri LAC-343 | Reduced Abdominal Subcutaneous Fat | Beneficial | Moderate |
| Lactobacillus gasseri LAC-343 | Reduced Abdominal Visceral Fat | Beneficial | Moderate |
| Lactobacillus gasseri LAC-343 | Reduced Body Mass Index | Beneficial | Small |
| Lactobacillus gasseri LAC-343 | Reduced Body Weight | Beneficial | Small |
| Lactobacillus gasseri LAC-343 | Reduced Hip Circumference | Beneficial | Small |
| Lactobacillus gasseri LAC-343 | Reduced Waist Circumference | Beneficial | Small |
| Lactobacillus gasseri LBV 150N | Reduced Abdominal Subcutaneous Fat Area | Beneficial | Moderate |
| Lactobacillus gasseri LBV 150N | Reduced Abdominal Visceral Fat Area | Beneficial | Moderate |
| Lactobacillus gasseri LBV 150N | Reduced BMI | Beneficial | Small |
| Lactobacillus gasseri LBV 150N | Reduced Body Weight | Beneficial | Small |
| Lactobacillus gasseri LBV 150N | Reduced Waist Circumference | Beneficial | Small |
| Lactobacillus gasseri LG-36 | Increased Serum High-Molecular Weight Adiponectin | Beneficial | Moderate |
| Lactobacillus gasseri LG-36 | Reduced Abdominal Visceral Fat | Beneficial | Moderate |
| Lactobacillus gasseri LG-36 | Reduced Body Weight | Beneficial | Small |
| Lactobacillus gasseri LQ-36 | Reduced Abdominal Fat | Beneficial | Moderate |
| Lactobacillus gasseri LQ-36 | Reduced Body Weight | Beneficial | Small |
| Lactobacillus gasseri SD-5585 | Increased Adiponectin Levels | Beneficial | Small |
| Lactobacillus gasseri SD-5585 | Reduced Abdominal Subcutaneous Fat | Beneficial | Moderate |
| Lactobacillus gasseri SD-5585 | Reduced Abdominal Visceral Fat | Beneficial | Moderate |
| Lactobacillus gasseri SD-5585 | Reduced Body Mass Index | Beneficial | Small |
| Lactobacillus gasseri SD-5585 | Reduced Body Weight | Beneficial | Small |
| Lactobacillus gasseri SD-5585 | Reduced Hip Circumference | Beneficial | Small |
| Lactobacillus gasseri SD-5585 | Reduced Waist Circumference | Beneficial | Small |
| Lactobacillus gasseri UALg-05 | Increased Serum High-Molecular Weight Adiponectin | Beneficial | Moderate |
| Lactobacillus gasseri UALg-05 | Reduced Abdominal Fat | Beneficial | Moderate |
| Lactobacillus gasseri UALg-05 | Reduced Body Mass Index | Beneficial | Small |
| Lactobacillus gasseri UALg-05 | Reduced Body Weight | Beneficial | Small |
| Lactobacillus gasseri UALg-05 | Reduced Hip Circumference | Beneficial | Small |
| Lactobacillus gasseri UALg-05 | Reduced Waist Circumference | Beneficial | Small |