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Regulation of abdominal adiposity by probiotics (Lactobacillus gasseri SBT2055) in adults with obese tendencies in a randomized controlled trial

  • 2010-03-10
  • European Journal of Clinical Nutrition 64(6)
    • Y. Kadooka
    • M. Sato
    • K. Imaizumi
    • A. Ogawa
    • Ken Ikuyama
    • Y. Akai
    • M. Okano
    • M. Kagoshima
    • T. Tsuchida

Abstract

Background/objectives: In spite of the much evidence for the beneficial effects of probiotics, their anti-obesity effects have not been well examined. We evaluated the effects of the probiotic Lactobacillus gasseri SBT2055 (LG2055) on abdominal adiposity, body weight and other body measures in adults with obese tendencies.

Subjects/methods: We conducted a multicenter, double-blind, randomized, placebo-controlled intervention trial. Subjects (n=87) with higher body mass index (BMI) (24.2-30.7 kg/m(2)) and abdominal visceral fat area (81.2-178.5 cm(2)) were randomly assigned to receive either fermented milk (FM) containing LG2055 (active FM; n=43) or FM without LG2055 (control FM; n=44), and were asked to consume 200 g/day of FM for 12 weeks. Abdominal fat area was determined by computed tomography.

Results: In the active FM group, abdominal visceral and subcutaneous fat areas significantly (P<0.01) decreased from baseline by an average of 4.6% (mean (confidence interval): -5.8 (-10.0, -1.7) cm(2)) and 3.3% (-7.4 (-11.6, -3.1) cm(2)), respectively. Body weight and other measures also decreased significantly (P<0.001) as follows: body weight, 1.4% (-1.1 (-1.5, -0.7) kg); BMI, 1.5% (-0.4 (-0.5, -0.2) kg/m(2)); waist, 1.8% (-1.7 (-2.1, -1.4) cm); hip, 1.5% (-1.5 (-1.8, -1.1) cm). In the control group, by contrast, none of these parameters decreased significantly. High-molecular weight adiponectin in serum increased significantly (P<0.01) in the active and control groups by 12.7% (0.17 (0.07, 0.26) microg/ml) and 13.6% (0.23 (0.07, 0.38) microg/ml), respectively.

Conclusion: The probiotic LG2055 showed lowering effects on abdominal adiposity, body weight and other measures, suggesting its beneficial influence on metabolic disorders.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactobacillus gasseriIncreased Adiponectin LevelsBeneficial
Small
Lactobacillus gasseriReduced Abdominal Visceral Fat AreaBeneficial
Moderate
Lactobacillus gasseriReduced Body WeightBeneficial
Small
Lactobacillus gasseriReduced Waist CircumferenceBeneficial
Small
Lactobacillus gasseri BNR17Increased Adiponectin LevelsBeneficial
Small
Lactobacillus gasseri BNR17Reduced Body WeightBeneficial
Small
Lactobacillus gasseri BNR17Reduced Visceral Fat MassBeneficial
Moderate
Lactobacillus gasseri KS-13Increased Serum High-Molecular Weight AdiponectinBeneficial
Moderate
Lactobacillus gasseri KS-13Reduced Abdominal FatBeneficial
Moderate
Lactobacillus gasseri KS-13Reduced Body Mass IndexBeneficial
Small
Lactobacillus gasseri KS-13Reduced Body WeightBeneficial
Small
Lactobacillus gasseri KS-13Reduced Hip CircumferenceBeneficial
Small
Lactobacillus gasseri KS-13Reduced Waist CircumferenceBeneficial
Small
Lactobacillus gasseri LAC-343Increased Adiponectin LevelsBeneficial
Small
Lactobacillus gasseri LAC-343Reduced Abdominal Subcutaneous FatBeneficial
Moderate
Lactobacillus gasseri LAC-343Reduced Abdominal Visceral FatBeneficial
Moderate
Lactobacillus gasseri LAC-343Reduced Body Mass IndexBeneficial
Small
Lactobacillus gasseri LAC-343Reduced Body WeightBeneficial
Small
Lactobacillus gasseri LAC-343Reduced Hip CircumferenceBeneficial
Small
Lactobacillus gasseri LAC-343Reduced Waist CircumferenceBeneficial
Small
Lactobacillus gasseri LBV 150NReduced Abdominal Subcutaneous Fat AreaBeneficial
Moderate
Lactobacillus gasseri LBV 150NReduced Abdominal Visceral Fat AreaBeneficial
Moderate
Lactobacillus gasseri LBV 150NReduced BMIBeneficial
Small
Lactobacillus gasseri LBV 150NReduced Body WeightBeneficial
Small
Lactobacillus gasseri LBV 150NReduced Waist CircumferenceBeneficial
Small
Lactobacillus gasseri LG-36Increased Serum High-Molecular Weight AdiponectinBeneficial
Moderate
Lactobacillus gasseri LG-36Reduced Abdominal Visceral FatBeneficial
Moderate
Lactobacillus gasseri LG-36Reduced Body WeightBeneficial
Small
Lactobacillus gasseri LQ-36Reduced Abdominal FatBeneficial
Moderate
Lactobacillus gasseri LQ-36Reduced Body WeightBeneficial
Small
Lactobacillus gasseri SD-5585Increased Adiponectin LevelsBeneficial
Small
Lactobacillus gasseri SD-5585Reduced Abdominal Subcutaneous FatBeneficial
Moderate
Lactobacillus gasseri SD-5585Reduced Abdominal Visceral FatBeneficial
Moderate
Lactobacillus gasseri SD-5585Reduced Body Mass IndexBeneficial
Small
Lactobacillus gasseri SD-5585Reduced Body WeightBeneficial
Small
Lactobacillus gasseri SD-5585Reduced Hip CircumferenceBeneficial
Small
Lactobacillus gasseri SD-5585Reduced Waist CircumferenceBeneficial
Small
Lactobacillus gasseri UALg-05Increased Serum High-Molecular Weight AdiponectinBeneficial
Moderate
Lactobacillus gasseri UALg-05Reduced Abdominal FatBeneficial
Moderate
Lactobacillus gasseri UALg-05Reduced Body Mass IndexBeneficial
Small
Lactobacillus gasseri UALg-05Reduced Body WeightBeneficial
Small
Lactobacillus gasseri UALg-05Reduced Hip CircumferenceBeneficial
Small
Lactobacillus gasseri UALg-05Reduced Waist CircumferenceBeneficial
Small
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