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Relationship between vitamin B12 levels and motor development: A systematic review.

  • 2024-10
  • Clinical nutrition ESPEN 63
    • Maria Eduarda Rodrigues Alves Dos Santos
    • Karollainy Gomes da Silva
    • Ana Patrícia da Silva Souza
    • Ana Beatriz Januário da Silva
    • Robson Feliciano da Silva
    • Erica Helena Alves da Silva
    • Sandra Lopes de Souza
    • Waleska Maria Almeida Barros

Study Design

Type
Systematic Review
Sample size
n = 684
Population
a total of 1,559 participants of both sexes
Methods
PRISMA method and registration in the PROSPERO database; search in PubMed, Scopus, PsycINFO, Web of Science, and ScienceDirect

Background and objectives

Nutrition plays a crucial role in the development and health of the human brain, from early stages to adulthood. The complex process of neurodevelopment necessitates interaction among various factors, with balance in the concentration of vital macronutrients and micronutrients being essential. Regarding micronutrients, vitamin B12 stands out, playing a vital role in the development and functioning of the motor nervous system. The objective was to investigate the influence of reduced levels of vitamin B12 on infant motor development and analyze the effects of supplementation on this aspect of development.

Methods

For this purpose, the criteria of the PRISMA method and registration in the PROSPERO database were used. The search was conducted in the following databases: PubMed (Medline), Scopus, PsycINFO, Web of Science, and ScienceDirect. A total of 684 records were initially identified.

Results

Of the eight included articles, there was diversity regarding geographical contexts and study designs. The final sample comprised a total of 1,559 participants of both sexes. Studies aimed at correcting low levels of vitamin B12 opted for supplementation, following various protocols that varied in dose, administration method, and duration. At the end of the studies, the serum level of this vitamin ranged from 131 pmol/L to 1141 pmol/L.

Conclusion

There is a complex array of factors contributing to reduced levels of vitamin B12, especially in the early stages of life, which significantly impacts infant motor development. Despite methodological variations among studies, evidence suggests that low levels of vitamin B12 may affect motor development and that supplementation could be an effective means of enhancing motor aspects in healthy children. However, due to the diversity of outcomes, it is important to promote comprehensive public policies to encourage appropriate interventions in this area.

Research Insights

  • Vitamin B12→Improved Motor Development

    evidence suggests that low levels of vitamin B12 may affect motor development and that supplementation could be an effective means of enhancing motor aspects in healthy children.

    Effect
    Beneficial
    Effect size
    Small
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