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Relationships between the genome and some phenotypical properties of Lactobacillus fermentum CECT 5716, a probiotic strain isolated from human milk

  • 2015-02-10
  • Applied Microbiology and Biotechnology 99(10)
    • Nívia Cárdenas
    • J. Laiño
    • S. Delgado
    • E. Jiménez
    • Marianela Juárez del Valle
    • Graciela Savoy De Giori
    • F. Sesma
    • B. Mayo
    • L. Fernández
    • J. G. LeBlanc
    • J. M. Rodríguez

Abstract

Lactobacillus fermentum CECT 5716, isolated from human milk, has immunomodulatory, anti-inflammatory, and anti-infectious properties, as revealed by several in vitro and in vivo assays, which suggests a strong potential as a probiotic strain. In this work, some phenotypic properties of L. fermentum CECT 5716 were evaluated, and the genetic basis for the obtained results was searched for in the strain genome. L. fermentum CECT 5716 does not contain plasmids and showed neither bacteriocin nor biogenic amine biosynthesis ability but was able to produce organic acids, glutathione, riboflavin, and folates and to moderately stimulate the maturation of mouse dendritic cells. No prophages could be induced, and the strain was sensitive to all antibiotics proposed by European Food Safety Authority (EFSA) standards, while no transmissible genes potentially involved in antibiotic resistance were detected in its genome. Globally, there was an agreement between the phenotype properties of L. fermentum CECT 5716 and the genetic information contained in its genome.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactobacillus fermentumImproved ImmunomodulationBeneficial
Moderate
Lactobacillus fermentumReduced Total InfectionsBeneficial
Moderate
Lactobacillus fermentum CECT5716Enhanced Phenotypic Maturation of Dendritic CellsBeneficial
Moderate
Lactobacillus fermentum CECT5716Improved ImmunomodulationBeneficial
Moderate
Lactobacillus fermentum CECT5716Reduced Infection RateBeneficial
Moderate
Lactobacillus fermentum CECT5716Reduced Inflammation LevelsBeneficial
Moderate
Lactobacillus fermentum LF61Enhanced Anti-Infective PropertiesBeneficial
Moderate
Lactobacillus fermentum LF61Improved ImmunomodulationBeneficial
Moderate
Lactobacillus fermentum LF61Increased Maturation of Mouse Dendritic CellsBeneficial
Moderate
Lactobacillus fermentum LF61Reduced Inflammation LevelsBeneficial
Moderate
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