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Research on the Effect of Pediococcus pentosaceus on Salmonella enteritidis-Infected Chicken

  • 2020-10-10
  • BioMed Research International 2020
    • D. Lan
    • XinYu Xun
    • YaoDong Hu
    • Nianzhen Li
    • Chaowu Yang
    • Xiaosong Jiang
    • Yiping Liu

Abstract

Salmonella enteritidis can cause significant morbidity and mortality in humans and economic loss in the animal industry. Improving the innate immunity is an effective method to prevent S. enteritidis infection. Pediococcus pentosaceus is a Gram-positive coccus which had probiotics properties. Numerous previously published studies reported that probiotics were beneficial to gut microbiota by changing the intestinal flora structure and inhibiting the harmful microbial growth to enhance the innate immunity. We investigated the immunological effects of P. pentosaceus on Salmonella-infected chickens by the following experiment. A total of 120 broilers from AA line were fed and divided into 2 groups (treated and control groups) for the experiment from day 1. The control group was fed with the basic diet, while the treated group was fed with the basic diet adding P. pentosaceus microcapsule with the bacterial concentration of 1 g/kg in the feed and bacterial counts 2.5 × 109 CFU/g. All the birds were given with 0.5 ml of S. enteritidis bacterial suspension (109 CFU/ml) through oral cavity at day 9. The number of dead birds was recorded and used in the analysis. The bacterial culture method and quantitative real-time PCR analysis were used to evaluate the effects of P. pentosaceus on chickens infected with S. enteritidis and to ascertain the mechanism of the effect. The results showed that the P. pentosaceus could restrain the pathogenicity of S. enteritidis and reduce the death rate from 44.4% to 23.3%. The flora in the caecum exhibited "rising-declining" trends, and the gene (TLR4, MyD88, TRAF6 NF-κB, IFN-β, TNF-a, IL6, and IL8) expression pattern was different between the experimental and control group. P. pentosaceus as a probiotic may competitively inhibit the growth of S. enteritidis and control the inflammatory response through regulating the gene expression which involved in the toll-like receptor pathway and inflammation pathway.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Pediococcus pentosaceus MAK99P15PReduced Colitis-Related MortalityBeneficial
Large
Pediococcus pentosaceus MAK99P15PReduced Pathogenicity of S. EnteritidisBeneficial
Large
Pediococcus pentosaceus MAK99P15PRegulated Gene Expression In InflammationBeneficial
Moderate
Pediococcus pentosaceus PP06Improved Gut MicrobiotaBeneficial
Moderate
Pediococcus pentosaceus PP06Reduced Mortality Rate from Salmonella Enteritidis InfectionBeneficial
Large
Pediococcus pentosaceus PP06Regulated Inflammatory ResponsesBeneficial
Moderate
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