Research Progress on Marine Active Substances in Improving Atherosclerosis.
- 2026-05-06
- Marine drugs 24(5)
- Chenyang Xie
- Jiapeng Qi
- Wenmei Huang
- Bei Chen
- Min Xu
- Shuji Liu
- Yongchang Su
- Yixiong Lin
- Kun Qiao
- Zhiyu Liu
- PubMed: 42188300
- DOI: 10.3390/md24050165
Study Design
- Type
- Review
Atherosclerosis is the primary pathological foundation of various cardiovascular and cerebrovascular diseases. Although existing treatment strategies exhibit certain efficacy, they still encounter limitations such as pronounced side effects and a single-target approach. The oceans have nurtured a rich diversity of organisms, and the secondary metabolites they generate possess novel structures, diverse activities, and unique mechanisms of action, offering new prospects for the development of anti-atherosclerotic drugs. This paper reviews advancements related to research on marine-derived active substances that possess anti-atherosclerotic activity, as well as current challenges in research on active substances, with the objective of laying a foundation for the development of anti-atherosclerotic drugs.