Revealing the mechanism of natural product-induced immunogenic cell death: opening a new chapter in tumor immunotherapy.
- 2024-10-09
- Frontiers in immunology 15
- Yukun Chen
- Zhenzhi Wang
- Chi Zhang
- Yisa Su
- Tian Zhou
- Kaiwen Hu
- PubMed: 39445013
- DOI: 10.3389/fimmu.2024.1470071
Study Design
- Type
- Review
- Funding
- Unclear
This review underscores the role of natural products in inducing immunogenic cell death (ICD) as a key strategy in tumor immunotherapy. It reveals that natural products can activate ICD through multiple pathways-apoptosis, autophagy, pyroptosis, and necroptosis-leading to the release of danger-associated molecular patterns (DAMPs), dendritic cell activation, and improved antigen presentation, which together stimulate a potent anti-tumor immune response. The study also demonstrates the enhanced therapeutic potential of combining natural products with immune checkpoint inhibitors. With a focus on translating preclinical findings into clinical practice, this review consolidates recent discoveries and suggests future research paths, offering both theoretical insights and practical guidance for advancing cancer immunotherapy.