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Safety and Effects of Lactobacillus paracasei TISTR 2593 Supplementation on Improving Cholesterol Metabolism and Atherosclerosis-Related Parameters in Subjects with Hypercholesterolemia: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

  • 2023-01-28
  • Nutrients 15(3)
    • Jurairat Khongrum
    • P. Yingthongchai
    • K. Boonyapranai
    • Wachira Wongtanasarasin
    • Paitoon Aobchecy
    • Suriya Tateing
    • A. Prachansuwan
    • Jaruwan Sitdhipol
    • K. Niwasabutra
    • Punnathon Thaveethaptaikul
    • P. Phapugrangkul
    • Pennapa Chonpathompikunlert

Abstract

Probiotics have the potential as a multi-target approach to modulate hypercholesterolemia associated with premature atherosclerosis. Various strains of Lactobacillus paracasei have been reported to affect hypercholesterolemia positively. This study aimed to investigate the effects of L. paracasei TISTR 2593 on lipid profile, cholesterol metabolism, and atherosclerosis according to the registration of Thai Clinical Trial Registry as identification number TCTR 20220917002. A total of 50 participants with hypercholesterolemia were randomly and equally assigned to consume L. paracasei TISTR 2593 or a placebo in maltodextrin capsules daily. Biomarkers of lipid profiles, oxidative stress state, inflammatory state, and other biological indicators were examined on days 0, 45, and 90. The results showed that subjects taking the L. paracasei TISTR 2593 could significantly reduce the level of serum low-density lipoprotein-cholesterol (p < 0.05), malondialdehyde (p < 0.001), and tumor necrosis factor-α (p < 0.01). Moreover, L. paracasei TISTR 2593 increased the level of serum apolipoprotein E (p < 0.01) and adiponectin (p < 0.001) significantly. No changes in serum total cholesterol, high-density lipoprotein-cholesterol, triglyceride, total bile acids, and monocyte chemoattractant protein-1 were observed during L. paracasei TISTR 2593 supplementation. Therefore, L. paracasei TISTR 2593 could be an adjuvant probiotic supplement to ameliorate hypercholesterolemia and prevent or delay the development of atherosclerosis.

Keywords: Lactobacillus paracasei; apolipoprotein E; clinical trial; hypercholesterolemia; inflammation; oxidative stress; probiotics.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactobacillus paracaseiIncreased Adiponectin LevelsBeneficial
Large
Lactobacillus paracaseiIncreased Apolipoprotein E LevelsBeneficial
Moderate
Lactobacillus paracaseiReduced Low-Density Lipoprotein LevelBeneficial
Moderate
Lactobacillus paracaseiReduced Malondialdehyde LevelsBeneficial
Large
Lactobacillus paracaseiReduced Tumor Necrosis Factor AlphaBeneficial
Moderate
Lactobacillus paracasei 431Increased Adiponectin LevelsBeneficial
Large
Lactobacillus paracasei 431Increased Apolipoprotein E LevelsBeneficial
Moderate
Lactobacillus paracasei 431Reduced Low-Density Lipoprotein LevelBeneficial
Moderate
Lactobacillus paracasei 431Reduced Serum Malondialdehyde LevelsBeneficial
Large
Lactobacillus paracasei 431Reduced Tumor Necrosis Factor AlphaBeneficial
Moderate
Lactobacillus paracasei DSM 13434Increased Adiponectin LevelsBeneficial
Large
Lactobacillus paracasei DSM 13434Increased Apolipoprotein E LevelsBeneficial
Moderate
Lactobacillus paracasei DSM 13434Reduced Hepatic Oxidative StressBeneficial
Large
Lactobacillus paracasei DSM 13434Reduced Inflammation LevelsBeneficial
Moderate
Lactobacillus paracasei DSM 13434Reduced Low-Density Lipoprotein LevelBeneficial
Moderate
Lactobacillus paracasei HA-196Increased Adiponectin LevelsBeneficial
Large
Lactobacillus paracasei HA-196Increased Apolipoprotein E LevelsBeneficial
Moderate
Lactobacillus paracasei HA-196No Change in HDL CholesterolNeutral
Small
Lactobacillus paracasei HA-196No Change in Serum TriglyceridesNeutral
Small
Lactobacillus paracasei HA-196No Improvement in Total CholesterolNeutral
Small
Lactobacillus paracasei HA-196Reduced Low-Density Lipoprotein LevelBeneficial
Moderate
Lactobacillus paracasei HA-196Reduced Serum Malondialdehyde LevelsBeneficial
Large
Lactobacillus paracasei HA-196Reduced Tumor Necrosis Factor AlphaBeneficial
Moderate
Lactobacillus paracasei HA-196Unchanged Monocyte Chemoattractant Protein-1 LevelsNeutral
Small
Lactobacillus paracasei HA-196Unchanged Total Bile Acids LevelsNeutral
Small
Lactobacillus paracasei IMC 502Increased Adiponectin LevelsBeneficial
Large
Lactobacillus paracasei IMC 502Increased Apolipoprotein E LevelsBeneficial
Moderate
Lactobacillus paracasei IMC 502Reduced Hepatic Oxidative StressBeneficial
Large
Lactobacillus paracasei IMC 502Reduced Inflammatory ResponseBeneficial
Moderate
Lactobacillus paracasei IMC 502Reduced Low-Density Lipoprotein CholesterolBeneficial
Moderate
Lactobacillus paracasei LPC09Increased Adiponectin LevelsBeneficial
Large
Lactobacillus paracasei LPC09Increased Apolipoprotein E LevelsBeneficial
Moderate
Lactobacillus paracasei LPC09Reduced LDL Cholesterol LevelsBeneficial
Moderate
Lactobacillus paracasei LPC09Reduced Malondialdehyde LevelsBeneficial
Large
Lactobacillus paracasei LPC09Reduced Tumor Necrosis Factor AlphaBeneficial
Moderate
Lactobacillus paracasei MCC1849Increased Adiponectin LevelsBeneficial
Large
Lactobacillus paracasei MCC1849Increased Apolipoprotein E LevelsBeneficial
Moderate
Lactobacillus paracasei MCC1849Reduced Low-Density Lipoprotein CholesterolBeneficial
Moderate
Lactobacillus paracasei MCC1849Reduced Malondialdehyde LevelsBeneficial
Large
Lactobacillus paracasei MCC1849Reduced Tumor Necrosis Factor AlphaBeneficial
Moderate
Lactobacillus paracasei subsp. paracasei UALpc-04Increased Adiponectin LevelsBeneficial
Large
Lactobacillus paracasei subsp. paracasei UALpc-04Increased Apolipoprotein E LevelsBeneficial
Moderate
Lactobacillus paracasei subsp. paracasei UALpc-04Reduced Hepatic Oxidative StressBeneficial
Large
Lactobacillus paracasei subsp. paracasei UALpc-04Reduced Low-Density Lipoprotein LevelBeneficial
Moderate
Lactobacillus paracasei subsp. paracasei UALpc-04Reduced Tumor Necrosis Factor AlphaBeneficial
Moderate
Lactobacillus paracasei UALpc-04Increased Adiponectin LevelsBeneficial
Large
Lactobacillus paracasei UALpc-04Increased Apolipoprotein E LevelsBeneficial
Moderate
Lactobacillus paracasei UALpc-04Reduced Low-Density Lipoprotein LevelBeneficial
Moderate
Lactobacillus paracasei UALpc-04Reduced Malondialdehyde LevelsBeneficial
Large
Lactobacillus paracasei UALpc-04Reduced Tumor Necrosis Factor AlphaBeneficial
Moderate
Lactobacillus paracasei VPro 224Increased Adiponectin LevelsBeneficial
Large
Lactobacillus paracasei VPro 224Increased Apolipoprotein E LevelsBeneficial
Moderate
Lactobacillus paracasei VPro 224Reduced Low-Density Lipoprotein LevelBeneficial
Moderate
Lactobacillus paracasei VPro 224Reduced Serum Malondialdehyde LevelsBeneficial
Large
Lactobacillus paracasei VPro 224Reduced Tumor Necrosis Factor AlphaBeneficial
Moderate
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