Samarium Diiodide-Mediated Radical Thioetherification of Alkyl Bromides with Disulfide Ethers.
- 2026-04-01
- The Journal of organic chemistry 91(14)
- PubMed: 41919575
- DOI: 10.1021/acs.joc.5c03233
An effective samarium diiodide-mediated radical thioetherification method for alkyl bromides with disulfide ethers is reported. This method represents the first realization of radical thioetherification of alkyl bromides using a samarium diiodide-induced system. Both reaction starting materials are simple and readily available basic reagents that can be easily purchased on the market. Meanwhile, this method demonstrates excellent functional group tolerance and a broad substrate scope. Notably, this reaction system proceeds under base-free and additive-free conditions.
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