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Screening and Characterization of Pediococcus acidilactici LC-9-1 toward Selection as a Potential Probiotic for Poultry with Antibacterial and Antioxidative Properties

  • 2023-01-17
  • Antioxidants 12(2)
    • Chong Li
    • Shaolong Wang
    • Si Chen
    • Xiaoying Wang
    • Xuejuan Deng
    • Guohua Liu
    • Wenhuan Chang
    • Y. Beckers
    • Huiyi Cai

Abstract

Growing interest has been focused on lactic acid bacteria as alternatives to antimicrobial growth promoters, which are characterized by the production of various functional metabolites, such as antimicrobial and antioxidants compounds. The present study was undertaken to evaluate a potential probiotic from the antioxidant perspective. LC-9-1, screened from the intestines of healthy animals, was revealed to be Pediococcus acidilactici on the basis of its morphological, biochemical, and molecular characteristics. The strain has excellent properties, including acid-production efficiency, antibacterial performance and antioxidant activity. The safety of the strain was also evaluated. Furthermore, the experiments in broiler chickens suggested that dietary LC-9-1 supplementation improved the growth performance and decreased the abdominal fat, and enhanced the antioxidant capability and intestinal innate immunity of broilers. Analysis of intestinal microbiota showed that a higher community diversity (Shannon index) was achieved. In addition to the significantly increased relative abundances of Pediococcus spp., beneficial genera such as Rothia spp. and Ruminococcus spp. were abundant, while opportunistic pathogens such as Escherichia-Shigella spp. were significantly reduced in LC-9-1-supplemented broilers. Collectively, such in-depth characterization and the available data will guide future efforts to develop next-generation probiotics, and LC-9-1 could be considered a potential strain for further utilization in direct-fed microbial or starter culture for fermentation.

Keywords: Pediococcus acidilactici; antibacterial; antioxidant; broiler chickens; intestinal microbiota; screening.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Pediococcus acidilacticiImproved Antioxidant FunctionBeneficial
Moderate
Pediococcus acidilacticiImproved Community Diversity of Intestinal MicrobiotaBeneficial
Moderate
Pediococcus acidilacticiImproved Growth PerformanceBeneficial
Large
Pediococcus acidilacticiIncreased Beneficial Gut BacteriaBeneficial
Moderate
Pediococcus acidilacticiReduced Abdominal FatBeneficial
Moderate
Pediococcus acidilacticiReduced Opportunistic PathogensBeneficial
Moderate
Pediococcus acidilactici KABP™-021Improved Abundance of Beneficial BacteriaBeneficial
Moderate
Pediococcus acidilactici KABP™-021Improved Antioxidant FunctionBeneficial
Moderate
Pediococcus acidilactici KABP™-021Improved Gut Microbiota DiversityBeneficial
Moderate
Pediococcus acidilactici KABP™-021Improved Intestinal Innate ImmunityBeneficial
Moderate
Pediococcus acidilactici KABP™-021Reduced Abdominal FatBeneficial
Moderate
Pediococcus acidilactici KABP™-021Reduced Opportunistic PathogensBeneficial
Moderate
Pediococcus acidilactici MAK92P26AImproved Antioxidant FunctionBeneficial
Moderate
Pediococcus acidilactici MAK92P26AImproved Gut Microbiota DiversityBeneficial
Moderate
Pediococcus acidilactici MAK92P26AImproved Intestinal Innate ImmunityBeneficial
Moderate
Pediococcus acidilactici MAK92P26AIncreased Beneficial Gut BacteriaBeneficial
Moderate
Pediococcus acidilactici MAK92P26AReduced Abdominal FatBeneficial
Moderate
Pediococcus acidilactici MAK92P26AReduced Opportunistic PathogensBeneficial
Moderate
Pediococcus acidilactici R1001Improved Antioxidant FunctionBeneficial
Moderate
Pediococcus acidilactici R1001Improved Growth PerformanceBeneficial
Large
Pediococcus acidilactici R1001Improved Gut Microbiota DiversityBeneficial
Moderate
Pediococcus acidilactici R1001Improved Intestinal ImmunityBeneficial
Moderate
Pediococcus acidilactici R1001Increased Beneficial Gut BacteriaBeneficial
Moderate
Pediococcus acidilactici R1001Reduced Abdominal FatBeneficial
Moderate
Pediococcus acidilactici R1001Reduced Opportunistic PathogensBeneficial
Moderate
Pediococcus acidilactici VPro29Improved Antioxidant FunctionBeneficial
Moderate
Pediococcus acidilactici VPro29Improved Growth PerformanceBeneficial
Large
Pediococcus acidilactici VPro29Improved Gut Microbiota DiversityBeneficial
Moderate
Pediococcus acidilactici VPro29Improved Intestinal Innate ImmunityBeneficial
Moderate
Pediococcus acidilactici VPro29Increased Gut Microbiota AbundanceBeneficial
Moderate
Pediococcus acidilactici VPro29Reduced Abdominal FatBeneficial
Moderate
Pediococcus acidilactici VPro29Reduced Pathogen InfectionBeneficial
Moderate
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