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Short- and long-term dynamics in the intestinal microbiota following ingestion of Bifidobacterium animalis subsp. lactis GCL2505

  • 2015
  • Bioscience of Microbiota, Food and Health 34(4)
    • Yoshiyuki Tanaka
    • K. Takami
    • Tomohiko Nishijima
    • Ryo Aoki
    • Takashi Mawatari
    • Takayuki Ikeda

Abstract

Bifidobacterium animalis subsp. lactis GCL2505 (B. lactis GCL2505) is able to survive passage through the intestines and proliferate. The daily dynamics of the intestinal bifidobacteria following ingestion of probiotics are not yet clear. Moreover, the effects of long-term ingestion of probiotics on the intestinal microbiota have not been well studied. Two experiments were performed in the present study. In Experiment 1, 53 healthy female volunteers received B. lactis GCL2505; B. bifidum GCL2080, which can survive but not proliferate in the intestine; or yogurt fermented with Lactobacillus delbrueckii subsp. bulgaricus and Streptococcus thermophilus for 2 weeks, and the daily dynamics of intestinal bifidobacteria were investigated. The number of fecal bifidobacteria significantly increased on day 1, and this was maintained until day 14 in the B. lactis GCL2505 ingestion group. However, no significant change in the number of fecal bifidobacteria was observed in the other groups throughout the ingestion period. In Experiment 2, 38 constipated volunteers received either B. lactis GCL2505 or a placebo for 8 weeks. Both the number of fecal bifidobacteria and the frequency of defecation significantly increased throughout the ingestion period in the B. lactis GCL2505 ingestion group. These results suggested that the proliferation of ingested bifidobacteria within the intestine contributed to a rapid increase in the amount of intestinal bifidobacteria and subsequent maintenance of these levels. Moreover, B. lactis GCL2505 improved the intestinal microbiota more effectively than non-proliferating bifidobacteria and lactic acid bacteria.

Keywords: Bifidobacterium; Bifidobacterium animalis subsp. lactis GCL2505; dynamics; intestinal microbiota; probiotics; proliferation.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Bifidobacterium animalisImproved Bowel Movement FrequencyBeneficial
Large
Bifidobacterium animalisImproved Intestinal Microbial CompositionBeneficial
Moderate
Bifidobacterium animalisIncreased Fecal BifidobacteriaBeneficial
Large
Bifidobacterium animalis subsp. lactisIncreased Bowel Movement FrequencyBeneficial
Moderate
Bifidobacterium animalis subsp. lactisIncreased Fecal BifidobacteriaBeneficial
Large
Bifidobacterium animalis subsp. lactis B420Improved Bowel Movement FrequencyBeneficial
Large
Bifidobacterium animalis subsp. lactis B420Improved Intestinal Microbial CompositionBeneficial
Moderate
Bifidobacterium animalis subsp. lactis B420Increased Fecal Bifidobacteria LevelsBeneficial
Large
Bifidobacterium animalis subsp. lactis BLC1Improved Intestinal MicrobiotaBeneficial
Moderate
Bifidobacterium animalis subsp. lactis BLC1Increased Bowel Movement FrequencyBeneficial
Moderate
Bifidobacterium animalis subsp. lactis BLC1Increased Fecal BifidobacteriaBeneficial
Large
Bifidobacterium animalis subsp. lactis BS-01Increased Bowel Movement FrequencyBeneficial
Moderate
Bifidobacterium animalis subsp. lactis BS-01Increased Fecal Bifidobacteria LevelsBeneficial
Large
Bifidobacterium animalis subsp. lactis CECT 8145Improved Intestinal MicrobiotaBeneficial
Moderate
Bifidobacterium animalis subsp. lactis CECT 8145Increased Bowel Movement FrequencyBeneficial
Moderate
Bifidobacterium animalis subsp. lactis CECT 8145Increased Fecal Bifidobacteria LevelsBeneficial
Large
Bifidobacterium animalis subsp. lactis LAFTI B94Increased Defecation FrequencyBeneficial
Moderate
Bifidobacterium animalis subsp. lactis LAFTI B94Increased Fecal Bifidobacteria LevelsBeneficial
Large
Bifidobacterium animalis subsp. lactis VK2Improved Bowel Movement FrequencyBeneficial
Large
Bifidobacterium animalis subsp. lactis VK2Increased Fecal Bifidobacteria LevelsBeneficial
Large
Bifidobacterium bifidum/lactis Bb-02Improved Intestinal MicrobiotaBeneficial
Moderate
Bifidobacterium bifidum/lactis Bb-02Increased Bowel Movement FrequencyBeneficial
Moderate
Bifidobacterium bifidum/lactis Bb-02Increased Fecal Bifidobacteria LevelsBeneficial
Large
Bifidobacterium lactisImproved Bowel Movement FrequencyBeneficial
Large
Bifidobacterium lactisImproved Intestinal MicrobiotaBeneficial
Moderate
Bifidobacterium lactisIncreased Intestinal Bifidobacteria LevelsBeneficial
Large
Bifidobacterium lactis B420Increased Defecation FrequencyBeneficial
Moderate
Bifidobacterium lactis B420Increased Fecal BifidobacteriaBeneficial
Large
Bifidobacterium lactis BL818Improved Intestinal MicrobiotaBeneficial
Moderate
Bifidobacterium lactis BL818Increased Defecation FrequencyBeneficial
Moderate
Bifidobacterium lactis BL818Increased Intestinal Bifidobacterium LevelsBeneficial
Large
Bifidobacterium lactis BLA80Improved Bowel Movement FrequencyBeneficial
Large
Bifidobacterium lactis BLA80Improved Maintenance of Intestinal Bifidobacteria LevelsBeneficial
Moderate
Bifidobacterium lactis BLA80Increased Intestinal Bifidobacterium LevelsBeneficial
Large
Bifidobacterium lactis BLC-1Improved Intestinal MicrobiotaBeneficial
Moderate
Bifidobacterium lactis BLC-1Increased Bowel Movement FrequencyBeneficial
Moderate
Bifidobacterium lactis BLC-1Increased Fecal BifidobacteriaBeneficial
Large
Bifidobacterium lactis BS01Increased Bowel Movement FrequencyBeneficial
Moderate
Bifidobacterium lactis BS01Increased Intestinal BifidobacteriaBeneficial
Large
Bifidobacterium lactis HA-194Improved Bowel Movement FrequencyBeneficial
Large
Bifidobacterium lactis HA-194Improved Intestinal Microbial CompositionBeneficial
Moderate
Bifidobacterium lactis HA-194Increased Fecal BifidobacteriaBeneficial
Large
Bifidobacterium lactis ISS BifImproved Intestinal MicrobiotaBeneficial
Moderate
Bifidobacterium lactis ISS BifIncreased Bowel Movement FrequencyBeneficial
Moderate
Bifidobacterium lactis ISS BifIncreased Fecal Bifidobacteria LevelsBeneficial
Large
Bifidobacterium lactis/longumImproved Bowel Movement FrequencyBeneficial
Large
Bifidobacterium lactis/longumImproved Intestinal Microbial CompositionBeneficial
Moderate
Bifidobacterium lactis/longumIncreased Fecal Bifidobacteria LevelsBeneficial
Large
Bifidobacterium lactis MAK16B42LImproved Intestinal Microbial CompositionBeneficial
Moderate
Bifidobacterium lactis MAK16B42LIncreased Bowel Movement FrequencyBeneficial
Moderate
Bifidobacterium lactis MAK16B42LIncreased Fecal Bifidobacteria LevelsBeneficial
Large
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