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Abstract

The spore-forming Bacillus coagulans has attracted attention for their therapeutic action in the colon. However, the mechanism of this action remains unclear. In this study, healthy subjects with mild intermittent constipation were supplemented with B. coagulans SNZ 1969 (BC) or the placebo for 8 weeks (n = 80). Then, we assessed colonic transit time (CTT), weekly complete spontaneous bowel movement (CSBM) scores, bowel discomfort symptom (BDS) scores, and 16S rRNA fecal microbiome profiles. The association between the critically altered gut microbiome and clinical outcomes was analyzed using redundancy analysis (RDA) and validated by receiver operating characteristic (ROC) curves. BC supplementation significantly improved CTT (p = 0.031), CSBM at weeks 2 (p = 0.045) and 9 (p = 0.038), and BDS at weeks 3 (p = 0.019) and 6 (p = 0.029) compared with the placebo, while altering the community composition of the gut microbiota. We also confirmed that BC was effectively delivered to the gut. Finally, the multivariate redundancy analysis concluded that BC-induced enrichment of Lactobacillales and diminishment of Synergistales were related to CTT improvements. This study provides important new data on how spore-forming B. coagulans SNZ 1969 contributes to improving gut motility and presents evidence supporting the use of B. coagulans SNZ 1969 in adults with mild intermittent constipation and habitual low intake of fruit and vegetables.

Keywords: Bowel discomfort symptom; Colon transit time; Complete spontaneous bowel movement; Human clinical study; Intermittent constipation; Probiotic.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Bacillus coagulansImproved Colonic Transit TimeBeneficial
Moderate
Bacillus coagulansIncreased Complete Spontaneous Bowel MovementsBeneficial
Moderate
Bacillus coagulansReduced Abdominal DiscomfortBeneficial
Moderate
Bacillus coagulans GBI-30, 6086Improved Intestinal MotilityBeneficial
Moderate
Bacillus coagulans GBI-30, 6086Increased Complete Spontaneous Bowel MovementsBeneficial
Moderate
Bacillus coagulans GBI-30, 6086Reduced Abdominal DiscomfortBeneficial
Moderate
Bacillus coagulans LactoSpore 1 billion CFUImproved Colonic Transit TimeBeneficial
Moderate
Bacillus coagulans LactoSpore 1 billion CFUIncreased Complete Spontaneous Bowel MovementsBeneficial
Moderate
Bacillus coagulans LactoSpore 1 billion CFUReduced Abdominal DiscomfortBeneficial
Moderate
Bacillus coagulans MTCC 5856Improved Colonic Transit TimeBeneficial
Moderate
Bacillus coagulans MTCC 5856Increased Weekly Spontaneous Bowel MovementsBeneficial
Moderate
Bacillus coagulans MTCC 5856Reduced Bowel Discomfort SymptomsBeneficial
Moderate
Bacillus coagulans ProDuraImproved Colonic Transit TimeBeneficial
Moderate
Bacillus coagulans ProDuraIncreased Complete Spontaneous Bowel MovementsBeneficial
Moderate
Bacillus coagulans ProDuraReduced Abdominal DiscomfortBeneficial
Moderate
Bacillus coagulans SC208Improved Intestinal MotilityBeneficial
Moderate
Bacillus coagulans SC208Increased Complete Spontaneous Bowel MovementsBeneficial
Moderate
Bacillus coagulans SC208Reduced Abdominal DiscomfortBeneficial
Moderate
Bacillus coagulans SNZ-1969Improved Colonic Transit TimeBeneficial
Moderate
Bacillus coagulans SNZ-1969Increased Frequency of Complete Spontaneous Bowel MovementsBeneficial
Moderate
Bacillus coagulans SNZ-1969Reduced Abdominal DiscomfortBeneficial
Moderate
Bacillus coagulans Unique IS-2Altered Gut Microbiota CompositionBeneficial
Large
Bacillus coagulans Unique IS-2Improved Colonic Transit TimeBeneficial
Moderate
Bacillus coagulans Unique IS-2Increased Complete Spontaneous Bowel MovementsBeneficial
Moderate
Bacillus coagulans Unique IS-2Reduced Abdominal DiscomfortBeneficial
Moderate
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