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Streptococcus salivarius K12 inhibits Candida albicans aggregation, biofilm formation and dimorphism

  • 2021-08-09
  • Biofouling 37(7)
    • M. Mokhtar
    • Nurul Alia Risma Rismayuddin
    • A. S. Mat Yassim
    • Hasna Ahmad
    • Ridhwan Abdul Wahab
    • S. Dashper
    • M. H. Arzmi

Abstract

Candida albicans causes candidiasis, particularly in immunocompromised patients. Streptococcus salivarius K12 (K12) is a probiotic isolated from a healthy oral cavity. The study aimed to determine the effect of K12 on C. albicans aggregation, biofilm formation and dimorphism. C. albicans ATCC MYA-4901, acquired immunodeficiency syndrome (AIDS) isolate (ALC2), and oral cancer isolate (ALC3) and K12 were used in the study. All C. albicans strains and K12 were grown in yeast peptone dextrose agar and brain heart infusion agar, respectively, prior to aggregation, biofilm and dimorphism assays. Auto-aggregation of C. albicans MYA-4901 and ALC2 was categorised as high, while the co-aggregation of the strains was low in the presence of K12. C. albicans total cell count decreased significantly when co-cultured with K12 compared with monocultured C. albicans biofilm (p < 0.05). Inhibition of yeast-to-hyphae transition was also observed when co-cultured with K12. In conclusion, K12 inhibits C. albicans aggregation, biofilm formation and dimorphism.

Keywords: Polymicrobial interactions; aggregation; biofilm; dimorphism; probiotic.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Streptococcus salivarius BLIS K12Inhibition of Yeast-to-Hyphae Transition in Candida AlbicansBeneficial
Moderate
Streptococcus salivarius BLIS K12Reduced Biofilm Formation by Candida albicansBeneficial
Large
Streptococcus salivarius BLIS K12Reduced Candida albicans AggregationBeneficial
Moderate
Streptococcus salivarius K12Reduced Biofilm Formation by Candida albicansBeneficial
Large
Streptococcus salivarius K12Reduced Candida albicans GrowthBeneficial
Moderate
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