Streptococcus thermophilus alters the expression of genes associated with innate and adaptive immunity in human peripheral blood mononuclear cells
- 2020-02-11
- PLOS ONE 15(2)
- Narges Dargahi
- Joshua C. Johnson
- V. Apostolopoulos
- PubMed: 32045425
- DOI: 10.1371/journal.pone.0228531
Abstract
Consumption of probiotics contributes to a healthy microbiome of the GIT leading to many health benefits. They also contribute to the modulation of the immune system and are becoming popular for the treatment of a number of immune and inflammatory diseases. The main objective of this study was to evaluate anti-inflammatory and modulatory properties of Streptococcus thermophilus. We used peripheral blood mononuclear cells from healthy donors and assessed modifications in the mRNA expression of their genes related to innate and adaptive immune system. Our results showed strong immune modulatory effects of S. thermophilus 285 to human peripheral blood mononuclear cells with an array of anti-inflammatory properties. S. thermophilus 285 reduced mRNA expression in a number of inflammatory immune mediators and markers, and upregulated a few of immune markers. S. thermophilus is used in the dairy industry, survives during cold storage, tolerates well upon ingesting, and their consumption may have beneficial effects with potential implications in inflammatory and autoimmune disorders.
Research Insights
| Supplement | Health Outcome | Effect Type | Effect Size |
|---|---|---|---|
| Streptococcus thermophilus | Increased Immune Marker Levels | Beneficial | Moderate |
| Streptococcus thermophilus MAK34S24T | Modulated Immune System | Beneficial | Large |
| Streptococcus thermophilus MAK34S24T | Reduced Inflammatory Immune Mediators | Beneficial | Moderate |
| Streptococcus thermophilus NBRC 13957 | Enhanced Immune System Function | Beneficial | Large |
| Streptococcus thermophilus NBRC 13957 | Increased Immune Factor Levels | Beneficial | Small |
| Streptococcus thermophilus NBRC 13957 | Reduced Inflammatory Immune Mediators | Beneficial | Moderate |
| Streptococcus thermophilus PXN 66 | Increased Immune Factor Levels | Beneficial | Small |
| Streptococcus thermophilus SD-5207 | Enhanced Immune Function | Beneficial | Moderate |
| Streptococcus thermophilus SD-5207 | Reduced Inflammatory Immune Mediators | Beneficial | Moderate |
| Streptococcus thermophilus SEBiotic | Increased Immune Marker Levels | Beneficial | Moderate |
| Streptococcus thermophilus SEBiotic | Modulated Immune Response | Beneficial | Moderate |
| Streptococcus thermophilus SEBiotic | Reduced Inflammatory Markers | Beneficial | Moderate |
| Streptococcus thermophilus SL-21 | Increased Immune Factor Levels | Beneficial | Small |
| Streptococcus thermophilus SL-21 | Reduced mRNA Expression of Inflammatory Immune Mediators | Beneficial | Moderate |
| Streptococcus thermophilus SP4 | Modulated Immune Response | Beneficial | Moderate |
| Streptococcus thermophilus SP4 | Reduced Inflammatory Immune Mediators | Beneficial | Moderate |
| Streptococcus thermophilus ST-21 | Improved Immune System Modulation | Beneficial | Moderate |
| Streptococcus thermophilus ST-21 | Reduced Inflammatory Immune Mediators Expression | Beneficial | Large |
| Streptococcus thermophilus ST-21 | Upregulated Immune Marker Expression | Beneficial | Small |
| Streptococcus thermophilus ST1447 | Modulated Immune Response | Beneficial | Moderate |
| Streptococcus thermophilus TH-4 | Enhanced Immune System Function | Beneficial | Large |
| Streptococcus thermophilus TH-4 | Increased Immune Marker Levels | Beneficial | Moderate |
| Streptococcus thermophilus UASt-09 | Enhanced Immune System Function | Beneficial | Large |
| Streptococcus thermophilus UASt-09 | Reduced Inflammatory Response | Beneficial | Large |
| Streptococcus thermophilus VPro 23 | Modulated Immune Response | Beneficial | Moderate |
| Streptococcus thermophilus VPro 23 | Reduced Proinflammatory Mediators | Beneficial | Moderate |
| Streptococcus thermophilus Y08 | Enhanced Immune System Function | Beneficial | Large |
| Streptococcus thermophilus Y08 | Increased Immune Marker Levels | Beneficial | Moderate |
| Streptococcus thermophilus Y08 | Reduced Inflammatory Markers | Beneficial | Moderate |
| Streptococcus thermophilus Y08 AF | Modulated Immune Response | Beneficial | Moderate |
| Streptococcus thermophilus Y08 AF | Reduced Inflammatory Response | Beneficial | Large |