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Streptococcus thermophilus extends lifespan through activation of DAF-16-mediated antioxidant pathway in Caenorhabditis elegans

  • 2022
  • Journal of Clinical Biochemistry and Nutrition 70(1)
    • Natsumi Desaka
    • Chinatsu Ota
    • Hitomi Nishikawa
    • K. Yasuda
    • N. Ishii
    • T. Bito
    • Yukio Kishinaga
    • Y. Naito
    • Yasuki Higashimura

Abstract

Streptococcus thermophilus bacteria, which are widely used as fermented starter for dairy production, exert various beneficial health effects. Nevertheless, even though pro-longevity effects of various probiotics have been reported, no report has described Streptococcus thermophilus effects on longevity. This study was conducted to evaluate Streptococcus thermophilus effects on lifespan extension and to elucidate the Streptococcus thermophilus-mediated longevity mechanism using Caenorhabditis elegans worms as a model animal. They were fed standard food (Escherichia coli OP50) or Streptococcus thermophilus from the young adult stage. Feeding with Streptococcus thermophilus, compared to Escherichia coli OP50, to Caenorhabditis elegans extend the lifespan, reduced lipofuscin accumulation, and maintain vigorous locomotion. Feeding with Streptococcus thermophilus did not alter the worm growth curve or the offspring number, indicating that the Streptococcus thermophilus-mediated lifespan extension is not attributable to caloric restriction. The qRT-PCR data showed that Streptococcus thermophilus increased the expression of daf-16 and some of its downstream antioxidant genes. Furthermore, the pro-longevity effects of Streptococcus thermophilus were decreased in loss-of-function mutant of daf-16. Results show that Streptococcus thermophilus extends the lifespan of Caenorhabditis elegans through DAF-16-mediated antioxidant pathway activation.

Keywords: Caenorhabditis elegans; hydrogen peroxide; lactic acid bacteria; longevity; oxidative stress.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Streptococcus thermophilusExtended LifespanBeneficial
Moderate
Streptococcus thermophilusMaintained Vigorous LocomotionBeneficial
Moderate
Streptococcus thermophilusReduced Lipofuscin AccumulationBeneficial
Moderate
Streptococcus thermophilus MAK34S24TExtended LifespanBeneficial
Moderate
Streptococcus thermophilus MAK34S24TIncreased Antioxidant Gene ExpressionBeneficial
Moderate
Streptococcus thermophilus MAK34S24TMaintained Vigorous LocomotionBeneficial
Moderate
Streptococcus thermophilus NBRC 13957Extended LifespanBeneficial
Moderate
Streptococcus thermophilus NBRC 13957Maintained Vigorous LocomotionBeneficial
Moderate
Streptococcus thermophilus NBRC 13957Reduced Lipofuscin AccumulationBeneficial
Moderate
Streptococcus thermophilus PXN 66Increased Antioxidant ActivityBeneficial
Large
Streptococcus thermophilus PXN 66Increased LifespanBeneficial
Moderate
Streptococcus thermophilus PXN 66Maintained Vigorous LocomotionBeneficial
Moderate
Streptococcus thermophilus PXN 66Reduced Lipofuscin AccumulationBeneficial
Moderate
Streptococcus thermophilus SEBioticIncreased LifespanBeneficial
Moderate
Streptococcus thermophilus SEBioticMaintained Physical Activity LevelBeneficial
Moderate
Streptococcus thermophilus SEBioticReduced Hepatic Oxidative StressBeneficial
Moderate
Streptococcus thermophilus SL-21Increased LifespanBeneficial
Moderate
Streptococcus thermophilus SL-21Maintained Vigorous LocomotionBeneficial
Moderate
Streptococcus thermophilus SL-21Reduced Lipofuscin AccumulationBeneficial
Moderate
Streptococcus thermophilus SP4Enhanced Antioxidant Gene ExpressionBeneficial
Moderate
Streptococcus thermophilus SP4Increased LifespanBeneficial
Moderate
Streptococcus thermophilus SP4Maintained Growth CurveNeutral
Small
Streptococcus thermophilus SP4Maintained Vigorous LocomotionBeneficial
Moderate
Streptococcus thermophilus SP4Reduced Lipofuscin AccumulationBeneficial
Moderate
Streptococcus thermophilus SP4Unchanged Offspring NumberNeutral
Small
Streptococcus thermophilus ST1447Increased LifespanBeneficial
Moderate
Streptococcus thermophilus ST1447Maintained Vigorous LocomotionBeneficial
Moderate
Streptococcus thermophilus ST1447Reduced Lipofuscin AccumulationBeneficial
Moderate
Streptococcus thermophilus ST-21Increased Antioxidant ActivityBeneficial
Large
Streptococcus thermophilus ST-21Increased LifespanBeneficial
Moderate
Streptococcus thermophilus ST-21Maintained Vigorous LocomotionBeneficial
Moderate
Streptococcus thermophilus ST-21Reduced Lipofuscin AccumulationBeneficial
Moderate
Streptococcus thermophilus TH-4Increased LifespanBeneficial
Moderate
Streptococcus thermophilus TH-4Maintained Vigorous LocomotionBeneficial
Moderate
Streptococcus thermophilus TH-4Reduced Lipofuscin AccumulationBeneficial
Moderate
Streptococcus thermophilus UASt-09Increased LifespanBeneficial
Moderate
Streptococcus thermophilus UASt-09Maintained Vigorous LocomotionBeneficial
Moderate
Streptococcus thermophilus UASt-09Reduced Lipofuscin AccumulationBeneficial
Moderate
Streptococcus thermophilus VPro 23Increased LifespanBeneficial
Moderate
Streptococcus thermophilus VPro 23Maintained Vigorous LocomotionBeneficial
Moderate
Streptococcus thermophilus VPro 23Reduced Lipofuscin AccumulationBeneficial
Moderate
Streptococcus thermophilus Y08Increased LifespanBeneficial
Moderate
Streptococcus thermophilus Y08Maintained Vigorous LocomotionBeneficial
Moderate
Streptococcus thermophilus Y08Reduced Lipofuscin AccumulationBeneficial
Moderate
Streptococcus thermophilus Y08 AFExtended LifespanBeneficial
Moderate
Streptococcus thermophilus Y08 AFIncreased Antioxidant Gene ExpressionBeneficial
Moderate
Streptococcus thermophilus Y08 AFMaintained Vigorous LocomotionBeneficial
Moderate
Streptococcus thermophilus Y08 AFReduced Lipofuscin AccumulationBeneficial
Moderate
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