- 2025-05-01
- Journal of veterinary internal medicine 39(3)
Study Design
- Type
- Randomized Controlled Trial (RCT)
- Sample size
- n = 7
- Population
- 20 dogs with chronic enteropathy and 20 healthy dogs
- Methods
- Prospective, randomized, placebo-controlled study; dogs with CE randomly assigned to placebo or vitK1 2.5 mg/kg PO q12h for 3 weeks; vitK1 concentrations measured by LC-MS/MS
- Duration
- 3 weeks
- Funding
- Unclear
Background
Information regarding measurement and supplementation of vitamin K1 (vitK1) in dogs with chronic enteropathy (CE) is limited.Hypothesis/objectives
Compare vitK1 concentrations of healthy dogs to dogs with CE and determine if supplementation with vitK1 increases vitK1 concentrations compared to placebo.Animals
Twenty client-owned dogs with CE and 20 healthy university-owned research colony dogs.Methods
Prospective, randomized, placebo-controlled study. Dogs with CE were randomly assigned to receive placebo or vitk1 2.5 mg/kg PO q12h for 3 weeks. Vitamin K concentrations were measured pre- and post supplementation using liquid chromatography tandem mass spectrometry and compared to vitK1 concentrations in the healthy cohort.Results
All healthy dogs had initial vitK1 median concentrations of 0.10 ng/mL (interquartile range [IQR], 0.05), which was similar to dogs that received either placebo (n = 5; 0.10 ng/mL; IQR, 0.05) or vitK1 (n = 7; 0.10 ng/mL; IQR, 0.05) before supplementation. Dogs with CE receiving vitK1 had increased vitK1 concentrations (12.5 ng/mL; IQR, 4.1) after 3 weeks of supplementation compared with baseline (0.10 ng/mL; p < 0.001), placebo group after 3 weeks (0.10 ng/mL; p < 0.0001) and healthy dogs (0.10 ng/mL; p < 0.004).Conclusions and clinical importance
Oral supplementation with vitK1 increased vitK1 concentration in the serum of dogs with CE, but a clinical benefit from increased vitK1 concentrations was not identified. The absence of difference in vitK1 concentrations between healthy and CE dogs before supplementation requires additional investigation.
Research Insights
| Supplement | Dose | Health Outcome | Effect Type | Effect Size | Source |
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