Suppressive effect of Lactobacillus gasseri OLL 2716 (LG21) on Helicobacter pylori infection in humans.
- 2001-05-01
- Journal of Antimicrobial Chemotherapy 47(5)
- Ichiko Sakamoto
- M. Igarashi
- Katsunori Kimura
- Atsushi Takagi
- Takeshi Miwa
- Yasuhiro Koga
- PubMed: 11328791
- DOI: 10.1093/JAC/47.5.709
Study Design
- Type
- Clinical Trial
- Sample size
- n = 31
- Population
- Humans infected with Helicobacter pylori
- Methods
- Controlled experimental study
- Highly Cited
Abstract
To examine the efficacy of Lactobacillus gasseri OLL2716 (LG21) as a probiotic for Helicobacter pylori in humans, 31 subjects infected with the bacterium ingested yogurt containing LG21 daily for an 8 week period. The [(13)C]urea breath test and assays of serum pepsinogens revealed a significant improvement following LG21 treatment. LG21 was thus determined to be effective in both suppressing H. pylori and reducing gastric mucosal inflammation.