Skip to main content
Supplement Research and Comparison WebsiteBest Price Guarantee
Supplement Research and Comparison Website

Synergy between Lactobacillus paracasei and its bacterial products to counteract stress-induced gut permeability and sensitivity increase in rats.

  • 2007-08
  • The Journal of Nutrition 137(8)
    • H. Eutamene
    • Florence Lamine
    • C. Chabo
    • V. Théodorou
    • F. Rochat
    • G. Bergonzelli
    • I. Corthésy-theulaz
    • J. Fioramonti
    • L. Buéno

Abstract

Stressful events result in the alteration of gut permeability and sensitivity. Lactobacillus paracasei NCC2461 (Lpa) therapy prevents antibiotic-induced visceral hyperalgesia in mice. This study aimed at evaluating the influence of 3 probiotic strains: Bifidobacterium lactis NCC362, Lactobacillus johnsonii NCC533, and Lpa on stress-mediated alterations of colorectal hyperalgesia, on gut paracellular permeability and whether bacteria and/or bacterial products present in the spent culture medium (SCM) were involved in the antinociceptive properties of the effective strain. Rat pups were separated from their mothers 3 h/d during postnatal d 2-14. At wk 13, gut paracellular permeability was determined as a percentage of urinary excreted (51)Cr-EDTA and visceral sensitivity to colorectal distension (CRD), assessed by abdominal muscle electromyography. Visceral sensitivity was also analyzed in adults rats subjected to partial restraint stress (PRS, 2 h restriction of body movements). Rats received either the probiotics resuspended in SCM or fresh growth medium as control for 2 wk. Maternal deprivation significantly increased colonic sensitivity in response to CRD and enhanced gut paracellular permeability compared with control rats. Only Lpa treatment significantly improved stress-induced visceral pain and restored normal gut permeability. Similarly, among the 3 probiotics tested, only Lpa prevented PRS-mediated visceral hyperalgesia. Both bacteria and bacterial products present in Lpa SCM were required for the antinociceptive properties against PRS. This study illustrates strain-specific effects and suggests a synergistic interplay between L. paracasei bacteria and bacterial products generated during fermentation and growth that confers the ability to suppress PRS-induced hypersensitivity in rats.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lacticaseibacillus paracasei Lpc-37Improved Gut PermeabilityBeneficial
Moderate
Lacticaseibacillus paracasei Lpc-37Prevented Visceral HyperalgesiaBeneficial
Moderate
Lacticaseibacillus paracasei Lpc-37Reduced Stress-Mediated Visceral HyperalgesiaBeneficial
Large
Lactobacillus paracasei LPC09Improved Epithelial PermeabilityBeneficial
Large
Lactobacillus paracasei LPC09Reduced Stress-Mediated Visceral HyperalgesiaBeneficial
Large
Lactobacillus paracasei LPC09Reduced Visceral PainBeneficial
Large
Back to top