The amino acid arginine: A comprehensive review.
- 2026-06
- Clinical nutrition ESPEN 73
- PubMed: 41887327
- DOI: 10.1016/j.clnesp.2026.103134
Study Design
- Type
- Review
Amino acids are the building blocks for producing proteins. They are essential to the efficient operation of body functions and the structure of cells. They supply the energy needed for normal cell division and growth. An amino acid that is classified as semi-essential or conditionally essential is arginine. Arginine is essential for maintaining the immune system and for treating several disorders. Numerous studies have demonstrated the effectiveness of using dietary supplements containing arginine and other amino acids in improving a range of medical conditions. This review will cover the classification, production, and molecular mechanisms of arginine, as well as its role as a biomarker in various diseases and its therapeutic efficacy in treating these conditions. It will also investigate the safety of arginine supplementation, as well as healthy and inadequate arginine levels. This review provides an overview of the critical importance of arginine as both a predictive and prognostic biomarker for the specified diseases and highlights its biological functions and therapeutic potential across a range of pathological conditions. To fully understand the overall function of this amino acid in the diagnosis, aetiology, enhancement, and treatment of many illnesses, more thorough research, including clinical studies, is required.
Research Insights
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