- 2026-04-02
- Molecular immunology 193
- Ling Lin
- Wei Li
- Xinjing Gao
- Qian Li
- Xin Zhou
- Weiyu Liu
- Xuelian Zhong
- Yunqing Yang
- Xibao Zhang
- Quan Luo
Study Design
- Type
- Observational
- Sample size
- n = 112
- Population
- 112 PV patients and 112 healthy controls
- Methods
- Cross-sectional observational study; blood cell counts to calculate SII, levels of Th17/Treg cells, cytokines, disease severity (PASI), and related factors analyzed; logistic regression identified independent risk factors
Objective
This cross-sectional observational study aimed to investigate the relationship between systemic immune-inflammation index (SII) and Th17/Treg cell imbalance in psoriasis vulgaris (PV) at a specific timepoint (upon admission), as well as its predictive value for disease severity.Methods
A total of 112 PV patients and 112 healthy controls were enrolled. Blood cell counts were used to calculate SII. Levels of Th17/Treg cells, cytokines (IL-17, IL-22, IL-10, TGF-β1), disease severity (PASI), and related factors were analyzed. Patients were classified into mild (MPV) or moderate-to-severe (MSPV) groups, and logistic regression identified independent risk factors for severity.Results
PV patients showed elevated neutrophils, SII, Th17, IL-17, and IL-22, but reduced lymphocytes, Treg, IL-10, and TGF-β1. SII positively correlated with PASI. MSPV patients had higher BMI, SII, Th17/Treg ratio, and cytokines (P < 0.05). BMI, SII, and Th17/Treg ratio were independent predictors of severity.Conclusion
This cross-sectional study indicates significant correlations of elevated SII levels in PV patients at a specific timepoint (upon admission) with Th17/Treg imbalance, disease severity (PASI), and poorer quality of life (DLQI/PLSI). These findings suggest the possibility of SII at a specific timepoint (upon admission) as a "snapshot" biomarker of the immuno-inflammatory status in PV.